文献类型：期刊文献

英文题名：Adipose-Derived Mesenchymal Stem Cells Combined With Extracellular Vesicles May Improve Amyotrophic Lateral Sclerosis

作者：Wang, Xichen[1];Zhang, Yong[1];Jin, Tian[1];Botchway, Benson O. A.[2];Fan, Ruihua[1,3];Wang, Lvxia[1,3];Liu, Xuehong[1]

机构：[1]Shaoxing Univ, Sch Med, Dept Histol & Embryol, Shaoxing, Peoples R China;[2]Zhejiang Univ, Sch Med, Inst Neurosci, Hangzhou, Peoples R China;[3]Shaoxing Univ, Sch Life Sci, Shaoxing, Peoples R China

年份：2022

卷号：14

外文期刊名：FRONTIERS IN AGING NEUROSCIENCE

收录：SCI-EXPANDED(收录号：WOS:000806095500001)、、Scopus(收录号：2-s2.0-85131555696)、WOS

语种：英文

外文关键词：adipose-derived mesenchymal stem cells; amyotrophic lateral sclerosis; neuronal injury; combinational therapy; extracellular vesicles

外文摘要：The complexity of central nervous system diseases together with their intricate pathogenesis complicate the establishment of effective treatment strategies. Presently, the superiority of adipose-derived mesenchymal stem cells (ADSCs) on neuronal injuries has attracted significant attention. Similarly, extracellular vesicles (EVs) are potential interventional agents that could identify and treat nerve injuries. Herein, we reviewed the potential effects of ADSCs and EVs on amyotrophic lateral sclerosis (ALS) injured nerves, and expound on their practical application in the clinic setting. This article predominantly focused on the therapeutic role of ADSCs concerning the pathogenesis of ALS, the protective and reparative effects of EVs on nerve injury, as well as the impact following the combined usage of ADSCs and EVs in ALS.