详细信息
文献类型:期刊文献
中文题名:Toll样受体:免疫治疗的新靶位
英文题名:Toll-like receptors: a new immune therapeutic target
作者:任光圆[1];晏春根[1];谢青[2]
机构:[1]绍兴文理学院医学院;[2]上海第二医科大学附属瑞金医院
年份:2004
卷号:23
期号:10
起止页码:718
中文期刊名:中国新药与临床杂志
外文期刊名:Chinese Journal of New Drugs and Clinical Remedies
收录:CSTPCD、、北大核心2000、CSCD2011_2012、北大核心、CSCD
语种:中文
中文关键词:免疫疗法;细胞因子类;配体;信号传导;Toll样受体
外文关键词:immune therapy; cytokines;ligands; singal transduction; Toll-like receptors
中文摘要:Toll样受体 (Toll likereceptors ,TLRs)是新近发现的模式识别受体 ,能识别病原相关分子模式 ,启动炎性应答通路而调节或控制先天与获得性免疫。以TLRs为靶位 ,抑制或激活TLRs表达或调控TLRs信号通路 。
外文摘要:The family of Toll-like receptors(TLRs) is a new pattern-recognition receptors(PRRs), which recognize specific pathogen-associated molecular patterns(PAMPs). Recognition of PAMPs by PRRs results in the activation of inflammatory process, which subsequently control the innate and adaptive immune response. It is possible that TLRs will offer validated remediable targets for anti-inflammatory therapeutics by controlling the expression and activation of TLRs.
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