文献类型：期刊文献

中文题名：Study of spatial signal transduction in bistable switches

英文题名：Study of spatial signal transduction in bistable switches

作者：Zhao, Qi[1,2];Yao, Cheng-Gui[3];Tang, Jun[4];Liu, Li-Wei[5]

机构：[1]Liaoning Univ, Sch Math, Shenyang 110036, Peoples R China;[2]Res Ctr Comp Simulating & Informat Proc Biomacrom, Shenyang 110036, Peoples R China;[3]Shaoxing Univ, Dept Math, Shaoxing 312000, Peoples R China;[4]China Univ Min & Technol, Coll Sci, Xuzhou 221008, Peoples R China;[5]Dalian Jiaotong Univ, Coll Sci, Dalian 116028, Peoples R China

年份：2016

卷号：11

期号：5

中文期刊名：物理学前沿：英文版

外文期刊名：FRONTIERS OF PHYSICS

收录：SCI-EXPANDED(收录号：WOS:000379063500001)、CSTPCD、、CSCD2015_2016、Scopus(收录号：2-s2.0-84964786220)、WOS、CSCD、PubMed

基金：This work was partially supported by the National Natural Science Foundation of China [Grant Nos. 11205077 (Q. Zhao), 11205103 (C. G. Yao), and 11105219 (J. Tang)] and the Innovation Team Project (Grant No. LT2015011) from the Education Department of Liaoning Province.

语种：英文

中文关键词：信号转导通路;双稳态开关;空间转换;扩散过程;空间系统;元素扩散;开关模块;开关特性

外文关键词：signal processing; reaction-diffusion model; nonlinear dynamics; spatial switch

外文摘要：Bistable switch modules are among the most important fundamental motifs in signal-transduction pathways. To better understand their spatial signal transduction, we model the diffusion process in the one-dimensional (1-D) domain. We find that when none of the elements diffuse, the response of the system exhibits a spatial switch-like property. However, when one of the elements is highly diffusible, the response of the system does not show any spatial switching behavior. Furthermore, we observe that the spatial responses of the system are more sensitive to the time constant of the switch when none of the elements are diffusible. Further, a slow loop keeps the system in the high steady state more positions than that in the fast loop. Finally, we consolidate our numerical results analytically by performing a mathematical method.