文献类型：期刊文献

中文题名：绍兴市区9929名健康体检人群血脂水平分类及分型的统计

英文题名：Statistical analysis of classification and phenotyping of blood lipid in 9 929 Shaoxing urban people receiving physical examination

作者：刘丽华[1];陈永对[1];陈菁[2]

机构：[1]绍兴文理学院医学院分子诊断实验室,生物化学教研室;[2]绍兴文理学院附属第一医院

年份：2006

卷号：10

期号：32

起止页码：26

中文期刊名：中国临床康复

外文期刊名：Chinese Journal of Clinical Rehabilitation

收录：CSTPCD、、北大核心2004、Scopus、CSCD_E2011_2012、北大核心、CSCD

语种：中文

中文关键词：高脂血症;胆固醇;甘油三酯类

中文摘要：目的:分析绍兴市区人群血脂水平分类及分型特征。方法:收集2004-01/2005-12在绍兴文理学院附属第一医院接受健康体检的绍兴市区人群9929名的血脂资料(男/女=5314/4615,年龄20～96岁),按年龄分为青年组(20～39岁)、中年组(40～49岁)、老年前期(50～59岁)及老年(60岁以上)4组。按中国“血脂异常防治建议”并参考美国“ATPⅢ指南”将所有数据进行血脂分类及分型并分析,具体标准:总胆固醇以5.2～5.69mmol/L为边缘性增高,>5.7mmol/L为高总胆固醇血症;三酰甘油以1.7～2.26mmol/L为边缘性增高,>2.26mmol/L为高三酰甘油血症;高密度脂蛋白胆固醇以<1.03mmol/L为低水平、1.03～1.54mmol/L为合适水平,1.55mmol/L以上为高水平。结果:①总胆固醇水平:4个年龄组中超过合适水平者基本都在30%以下,只有老年女性达到了34%。他们中约15%可以诊断为高胆固醇血症,老年女性高胆固醇血症者比例达到19.2%。②三酰甘油的分布:在0.56mmol/L以下者约为5%;在1.13mmol/L以下者约为35%,在1.69mmol/L以上者各组约为35%,>2.26mmol/L者约为17%。③总胆固醇、三酰甘油都在合适范围者青年组为49%,中年组和老年前期组约为47%,老年组约为44%;从高血脂分型来说,不论是边缘性增高或明确的高血脂都是高三酰甘油略多与高总胆固醇。④高密度脂蛋白胆固醇:低水平的分布频率在各组中大致为4%,在60岁以下人群中女性(4.3%)略高于男性(3.9%),而在老年人中则相反(男性4.1%,女性3.1%);高水平者在各组男性和女性人群中约为60%,但在老年女性中高达71.5%;高高密度脂蛋白胆固醇多见于高三酰甘油者(男性16.1%,女性15.2%),而低高密度脂蛋白胆固醇则多见于三酰甘油边缘性增高型(男性15.0%,女性13.1%)。结论:绍兴市城区人群血脂异常处于一个较高的水平(异常者已达1/2),并且有年轻化的趋势(青年人中也达到了约50%)。

外文摘要：AIM： To analyze the classification and phenotype characteristics of blood lipid in urban populations of Shaoxing. METHODS： Data were obtained from 9 929 urban people in Shaoxing, who received health examination in the First Hospital Affiliated to Shaoxing University of Sciences and Arts between January 2004 and December 2005 （5 314 males and 4 615 females, aged 20-96 years）. The subjects were divided into 4 groups according to the age： young group （aged 20-39 years）, middle age group （aged 40-49 years）, pre-senior group （aged 50-59 years） and senior group （above 60 years）, The data of blood lipid were classified, grouped and analyzed according to Recommended Guidelines for Prevention and Treatment of Dyslipidemia of China and NCEP ATP III of US with specific standards as the following： Patients with the total cholesterol （TC） between 5.2 and 5.69 mmol/L were taken as borderlineincreasing, and those 〉 5.7 mmol/L were taken as hypercholesteremia. Patients with the level of triglyceride （TG） at 1.7-2.26 mmol/L were taken as borderline-increasing, and those 〉 2.26 mmol/L were taken as hypertriacylolycerolemia. Patients with the level of high density lipoprotein-cholesterol （HDL-C） 〈 1.03 mmol/L were taken as low level, and those at 1.05-1.54 mmol/L were considered at proper level, while those below 1.55 mmol/L were taken as high level. RESULTS：①Level of TC： subjects above proper level was below 30% in four groups, while that in elder women was 34%, 15% of which could be diagnosed as hypercholesteremia, and 19.2% of elderly women were hypercholesteremia. ②Distribution of TG： 5% of patients below 0.56 mmol/L, 35% below .1.13 mmol/L, 35% above 1.69 mmol/L in each group, and 17% 〉 2.26 mmol/L. ③Subjects with the levels of TC and TG within proper level accounted for 49% in young group, and was 47% in middle age group and pre-senior group, while it was 44% in senior group. View from the phenotype, subjects with no matter borderline-increasing or definite hyperlipemia all higher in hypertrilglucerol, than in high TC.④Level of HDL-C： The distribution of low level in each group was about 4%, and that in females aged below 60 years （4.3%） was a little higher than in males （3.9%）. However, it＇ was just the opposite in senior people （male 4.1%, female 3.1%）. Subjects of high level in males and females of each group accounted for 60%, while it was 71.5% in senior females. High HDL-C was usually associated with subjects with high TG （male 16.1%, female 15.2%）,but low HDL-C was usually found in subjects with the TG level slightly higher than the standard （male 15.0%, female 13.1%）. CONCLUSION： The abnormal blood lipid in Shaoxing urban population is in a higher level （with a ratio of 1/2）, moreover, more and more young people are suffering from it. which accounts for 50%.