文献类型：期刊文献

英文题名：Protective Effect of Schisandra chinensis Extract Against Ethanol-Induced Gastric Ulcers in Mice by Promoting Anti-inflammatory and Mucosal Defense Mechanisms

作者：Si, Wen-zhang[1,2];Hu, Xin-xin[2,3];Shen, Chen[2];Luo, Ming-xiao[2];Xuan, Yan-han[2];Fu, Hai-jing[4];Xing, Guiying[2];Zhang, Hua-fang[5];Zhang, Jian[5];Liu, Zheng[2,5]

机构：[1]Shaoxing Univ, Affiliated Hosp, Dept Gen Surg, Shaoxing Municipal Hosp, Shaoxing 312000, Zhejiang, Peoples R China;[2]Shaoxing Univ, Dept Forens Toxicol, Forens Ctr, 900 Chengnan Rd, Shaoxing 312000, Zhejiang, Peoples R China;[3]Cixi Matern & Child Hlth Care Hosp, Ningbo 315000, Zhejiang, Peoples R China;[4]Shaoxing Univ, Chem Coll, Shaoxing 312000, Zhejiang, Peoples R China;[5]Shaoxing Univ, Dept Pharmacol, Coll Med, Shaoxing 312000, Zhejiang, Peoples R China

年份：2020

卷号：30

期号：6

起止页码：780

外文期刊名：REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY

收录：SCI-EXPANDED(收录号：WOS:000576308900005)、、Scopus(收录号：2-s2.0-85092130416)、WOS

基金：This work was funded by the Public Welfare Technology Applied Research Projects in Zhejiang Province, China (No. 2016C33191), the Science and Technology Planning Project of Shaoxing City, China (No. 2017B70050), and the National Training Program of Innovation and Entrepreneurship for College Students (No. 2017R10349001).

语种：英文

外文关键词：Acute alcohol intake; Cytokines; Gastric mucosa damage; Oxidative stress; Pathological change

外文摘要：Schisandra chinensis(Turcz.) Baill., Schisandraceae, is a common Chinese traditional medicine for the treatment of nervous system disorders and cardiovascular diseases. However, little is known about its efficacy in treating gastrointestinal diseases. In the present study, the protective effect of the ethanol extract ofS. chinensisagainst ethanol-induced acute gastric lesions was investigated in mice. Furthermore, we developed a method based on high-performance liquid chromatography for the quantification of bioactive lignans with a dibenzocyclooctadiene skeleton. The ethanol extract ofS. chinensissignificantly decreased the ulcer index, sheltered mucosa from lesions, increased levels of superoxide dismutase, decreased malondialdehyde levels, and downregulated plasma levels of tumor necrosis factor-alpha and interleukin-1 beta. Our findings demonstrated the gastroprotective properties of the ethanol extract ofS. chinensis.