文献类型：期刊文献

英文题名：Photoinduced decarboxylative radical cascade alkylation/cyclization of benzimidazole derivatives with an aliphatic carboxylic acid via ligand-to-iron charge transfer

作者：Xu, Yan[1];Wang, ChenJing[1];Lv, Chun[1];Wang, Jianjie[1];Zhang, Qian[1];Wang, Jiayang[2];Shen, Run-Pu[4];Sun, Bin[1,3];Jin, Can[1,3]

机构：[1]Zhejiang Univ Technol, Coll Pharmaceut Sci, Collaborat Innovat Ctr Yangtze River Delta Reg Gre, Hangzhou 310014, Peoples R China;[2]HuZhou Univ, Sch Life Sci, Huzhou, Zhejiang, Peoples R China;[3]Minist Educ, Key Lab Green Pharmaceut Technol & Related Equipme, Hangzhou, Peoples R China;[4]Shaoxing Univ, Zhejiang Engn Res Ctr Fat soluble Vitamin, Shaoxing 312000, Peoples R China

年份：2024

外文期刊名：NEW JOURNAL OF CHEMISTRY

收录：SCI-EXPANDED(收录号：WOS:001284475200001)、、EI(收录号：20243316868808)、Scopus(收录号：2-s2.0-85200898023)、WOS

基金：This work was supported by the National Natural Science Foundation of China (Grand No. 22078299 and 22108250) and the Opening Project of Zhejiang Engineering Research Center of Fat-soluble Vitamin (202303 and 202201). We are also grateful to the College of Pharmaceutical Sciences, Zhejiang University of Technology and Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals for the financial help.

语种：英文

外文摘要：The photoinduced decarboxylative radical cascade alkylation/cyclization strategy of diverse benzimidazoles containing unactivated alkene moieties towards the synthesis of polycyclic benzimidazoles via ligand-to-metal-charge-transfer (LMCT) has been developed. Specifically, the reaction initiates the decarboxylation of alkyl carboxylic acids through light-induced charge transfer from the ligand to iron, resulting in the formation of alkyl radical centers. Moreover, the protocol has prominent features, such as a broad substrate scope, high regioselectivity, mild reaction conditions, operational simplicity and readily available air acting as the sole oxidant.