文献类型：期刊文献

英文题名：Investigating the causal association between systemic lupus erythematosus and migraine using Mendelian randomization analysis

作者：Xu, Danfeng[1,2];Wu, Bing[1,2,3]

机构：[1]Shaoxing Univ, Shaoxing Cent Hosp, Hosp Affiliated, Shaoxing, Peoples R China;[2]Shaoxing Univ, Cent Lab, Cent Hosp, Shaoxing, Peoples R China;[3]Shaoxing Univ, Shaoxing Cent Hosp, Cent Hosp, Hua Yu Rd 1, Shaoxing 312030, Peoples R China

年份：2024

外文期刊名：HEADACHE

收录：SCI-EXPANDED(收录号：WOS:001221566000001)、、Scopus(收录号：2-s2.0-85191833256)、WOS

基金：We gratefully thank the authors of Bentham et al.14 for providing genetic data. We also want to acknowledge the participants and investigators of the FinnGen study. This study was supported by Keqiao Clinical Funding (2022KZ71). We thank for its linguistic assistance during the preparation of this manuscript ().

语种：英文

外文关键词：causal association; Mendelian randomization; migraine; systemic lupus erythematosus

外文摘要：Objective: To assess whether systemic lupus erythematosus (SLE) may be genetically causally associated with migraine, including the two primary subtypes: migraine with aura (MWA) and migraine without aura (MWoA). Background: The association between SLE and migraine has been investigated extensively. Previous studies have shown a higher prevalence of migraine in patients with SLE, although the exact relationship remains unclear. This study investigated the potential causal association between SLE and migraine using the powerful analytical tool of Mendelian randomization (MR). Methods: We performed two-sample MR analysis of publicly available summary statistic datasets using inverse variance-weighted (IVW), weighted median, and MR-Egger methods based on an SLE genome-wide association study (GWAS; 5201 cases; 9066 controls; the exposure frequency is 36.5%) as an exposure and migraine GWAS (15,905 cases; 264,662 controls) in individuals with European ancestry as outcomes, focusing on the two migraine subtypes MWA (6780 cases; 264,662 controls) and MWoA (5787 cases; 264,662 controls). Thepleiotropy and heterogeneity were performed. Results: We selected 42 single-nucleotide polymorphisms from SLE GWAS as instrumental variables (IVs) for SLE on migraine, and 41 SNP IVs for SLE on MWA or MWoA. The IVW (odds ratio [OR] = 1.01, 95% confidence interval [CI] = [0.99, 1.03], p = 0.271), weighted median (OR = 1.00, 95% CI = [0.97, 1.03], p = 0.914), and MR-Egger (OR = 1.04, 95% CI = [0.99, 1.09], p = 0.153) methods showed no causal effect of SLE on migraine. A causal effect of SLE was observed on MWA (IVW: OR = 1.05, 95% CI = [1.02, 1.08], p = 0.001; weighted median: OR = 1.05, 95% CI = [1.01, 1.10], p = 0.018; MR-Egger: OR = 1.07, 95% CI = [1.01, 1.14], p = 0.035 and p(IVW) < 0.017 [Bonferroni correction]) but not MWoA (IVW: OR = 0.99, 95% CI = [0.96, 1.02], p = 0.331; weighted median: OR = 0.98, 95% CI = [0.94, 1.03], p = 0.496; MR-Egger: OR = 1.02, 95% CI = [0.95, 1.09], p = 0.652). The results showed no significant pleiotropy or heterogeneity. Conclusion: Our MR analysis demonstrated the complex relationship between SLE and migraine, suggesting a potential effect of SLE on the risk of MWA but not MWoA. These findings can aid in the development of improved subtype-specific management of migraine in patients with SLE.