文献类型：期刊文献

英文题名：Acute hepatotoxicity of multimodal targeted imaging contrast agent NaLuF4:Gd,Yb,Er-PEG/PEI-FA in mice

作者：Chen, Yuan[1];Fei, Xiaoxiao[2];Ye, Chenqiao[1];Qian, Qinqing[1];Ye, Zhiqiu[1];Xie, Siqi[1];Chen, Jiamin[1];Zhu, Mingliao[1];Ran, Na[1];Hou, Mingsheng[3];Xu, Lin[4];Yu, Zhangsen[1]

机构：[1]Shaoxing Univ, Sch Med, Shaoxing 312000, Peoples R China;[2]Cixi Matern & Child Hlth Care Hosp, Cixi 315300, Peoples R China;[3]Shaoxing Hosp Tradit Chinese Med, Shaoxing 312000, Peoples R China;[4]Shaoxing Univ, Affiliated Hosp, Shaoxing 312000, Peoples R China

年份：2019

卷号：44

期号：7-9

起止页码：621

外文期刊名：JOURNAL OF TOXICOLOGICAL SCIENCES

收录：SCI-EXPANDED(收录号：WOS:000514252200018)、、Scopus(收录号：2-s2.0-85071750383)、WOS

基金：We are grateful for the financial support from the College Students Science and Technology Innovation Project of Zhejiang Province, China (2017R428021), National College Students Innovation and Entrepreneurship Training Program, China (201710349011), National Natural Science Foundation of China (51402195), Educational Commission of Zhejiang Province, China (Y201839726, Y201225801), University Laboratory Research Project of Zhejiang Province, China (YB201722), Science and Technology Plan in Shaoxing City (2018C10011).

语种：英文

外文关键词：Trimodal Imaging Contrast Agent; Upconversion Nanoparticles; NaLuF4:Gd,Yb,Er-PEG/PEI-FA; Biodistribution; Acute hepatotoxicity

外文摘要：In the past few decades, upconversion nanoparticles (abbreviated as UCNPs) have been more widely applied in the biomedical fields, such as in vitro and in vivo upconversion fluorescent bioimaging, photodynamic therapy, biological macromolecular detection, imaging mediated drug delivery and so on. But meanwhile, there is still not much research on the acute toxicity of upconversion nanoparticles in vivo, such as acute hepatotoxicity. In this work, we studied the in vivo biodistribution and acute hepatotoxicity of multimodal targeted contrast agent NaLuF4:Gd,Yb,Er-PEG/PEI-FA nanoprobe, which were synthesized by the solvothermal method and modified with Polyethylene glycol (PEG), Polyetherimide (PEI), folic acid (FA) on the surface. The acute hepatotoxicity in mice was systematically assessed after tail vein injection of different concentration of UCNPs. The results showed that NaLuF4:Gd,Yb,Er-PEG/PEI-FA nanoparticles with an average diameter of 44.5 +/- 10.4 nm, and three typical upconversion fluorescence emission bands at 520 nm, 540 nm and 660 nm under the excitation of 980 nm laser. In vivo distribution experiments results demonstrated that approximately 87% of UCNPs injected through the tail vein accumulate in the liver. In the acute hepatotoxicity test, the intravenously injection dose of UCNPs was 10, 40, 70 and 100 mg/kg, respectively. The body weight, blood routine, serum biochemistry, histomorphology and liver oxidative stress were detected and observed no significant acute hepatotoxicity damage under the injection dose of 100 mg/kg. In conclusion, NaLuF4:Gd,Yb,Er-PEG/PEI-FA nanoprobes are safe and reliable, and have potential applications in the field of tumor targeted multimodal imaging.