文献类型：期刊文献

英文题名：Selective Synthesis of Alkynylated Isoquinolines and Biisoquinolines via Rh-III Catalyzed C-H Activation/1,3-Diyne Strategy

作者：Feng, Ruokun[1];Ning, Hanqi[1];Su, Han[1];Gao, Yuan[1];Yin, Haotian[1];Wang, Yudan[1];Yang, Zhen[1];Qi, Chenze[1]

机构：[1]Shaoxing Univ, Dept Chem, Zhejiang Key Lab Alternat Technol Fine Chem Proc, Shaoxing 312000, Peoples R China

年份：2017

卷号：82

期号：19

起止页码：10408

外文期刊名：JOURNAL OF ORGANIC CHEMISTRY

收录：SCI-EXPANDED(收录号：WOS:000412789000046)、、EI(收录号：20182205258618)、Scopus(收录号：2-s2.0-85044908643)、WOS、CCR-EXPANDED(收录号：WOS:000412789000046)

基金：Funding from Science Technology Department of Zhejiang Province (No. LQ15B020002, Feng, R K. and LQ13B020002, Yang, Z.) and NSFC (No. 21172149, Qi, C. Z. and 21302129, Yang, Z.) is highly acknowledged.

语种：英文

外文关键词：Activation analysis - Catalysis - Chemical activation - Ketones

外文摘要：Described herein is a convenient and highly selective synthesis of alkynylated isoquinolines and biisoquinolines from various aryl ketone O-pivaloyloxime derivatives and 1,3-diynes via rhodium-catalyzed C-H bond activation. In this transformations, alkynylated isoquinolines, 3,4'- and 3,3'-biisoquinolines could be obtained respectively through changing the reaction conditions. Mechanistic investigation revealed that the C-H activation of aryl ketone O-pivaloyloxime was the key step to this reaction.