文献类型：期刊文献

英文题名："mTOR Signaling Pathway": A Potential Target of Curcumin in the Treatment of Spinal Cord Injury

作者：Lin, Jingquan[1];Huo, Xue[2];Liu, Xuehong[1]

机构：[1]Shaoxing Univ, Med Coll, Dept Histol & Embryol, Shaoxing, Zhejiang, Peoples R China;[2]Zhejiang Univ, Sch Med, Inst Neurosci, Hangzhou, Zhejiang, Peoples R China

年份：2017

卷号：2017

外文期刊名：BIOMED RESEARCH INTERNATIONAL

收录：SCI-EXPANDED(收录号：WOS:000402989200001)、、Scopus(收录号：2-s2.0-85021670040)、WOS

基金：This work was supported by the Natural Science Foundation of Zhejiang Province (no. LY15H170001), the Public Technology Applied Research Projects Foundation of Shaoxing City (nos. 2013D10035 and 2015B70040), and the National Undergraduate Innovation Training Program (no. 201610349007).

语种：英文

外文摘要：The purpose of this review is to discuss the possibility of the treatment of spinal cord injury (SCI) with curcumin via regulating the mTOR signaling pathway, which may provide another strong support for curcumin to be a promising medicine applied to the treatment of SCI. Curcumin is termed as a multifunctional targeting therapy drug that regulates the mTOR signaling pathway in the treatment of numerous diseases. Previous research has already revealed that mTOR signaling pathway plays a vital role in prognosis, which involves the axon regeneration and autophagy. This review discusses a potential mechanism that curcumin suppresses the activation of this pathway and ameliorates the microenvironment of axons regeneration which would provide a new way that induces autophagy appropriately.