文献类型：期刊文献

英文题名：Efficacy and safety of self-made covered coronary stent in the treatment of coronary artery perforation

作者：An, Wen[1];Ye, Jian[1,2];Han, Bingyu[1];Wang, Xu[1];Han, Chao[1];Gao, Junqing[1];Liu, Zongjun[1]

机构：[1]Shanghai Univ Tradit Chinese Med, Putuo Hosp, Dept Cardiol, Shanghai 200062, Peoples R China;[2]Shaoxing Univ, Affiliated Hosp, Dept Cardiol, Shaoxing, Peoples R China

年份：2023

卷号：23

期号：1

外文期刊名：BMC CARDIOVASCULAR DISORDERS

收录：SCI-EXPANDED(收录号：WOS:001097245300001)、、Scopus(收录号：2-s2.0-85175701704)、WOS

基金：Not applicable.

语种：英文

外文关键词：Coronary covered stent; Coronary perforation; Thrombus; CaIMR

外文摘要：Objective To observe the efficacy and safety of self-made covered coronary stent in the treatment of coronary artery perforation.Methods Covered coronary stent was prepared by wrapping 3 M film on the surface of coronary stents. The beagle dogs were divided into control group and experimental group. A drug-eluting stent (DES) was implanted in the control group. The covered stent was applied to block the coronary branches of beagle dogs. The CaIMR value after stent placement was calculated by FlashAngio software. The effect of blocking the coronary branches on blood flow was observed by coronary angiography (CAG). The condition of the implanted stent was observed by optical coherence tomography (OCT), and the histopathologic examination of the coronary vessel implanted stent was performed by HE staining.Results The best number of layers was 2. Compared with the control group, the CaIMR of the experimental group increased (p < 0.05). A lot of in-stent thrombosis were found in the experimental group and obvious blood flow obstruction during follow-up. HE staining showed that stents implanted in the two groups adhered well to the wall of the blood vessel, but in-stent thrombosis and intimal hyperplasia were founded in the experimental group, while the in-stent restenosis was not founded.Conclusion The self-made coronary covered stent can effectively block the leakage caused by coronary perforation, but the stent endothelialization is poor, which easily causes stent thrombosis and restenosis, so it is not recommended as a routine remedy.