文献类型：期刊文献

英文题名：Apelin-13 can regulate adipose-derived mesenchymal stem cells to improve traumatic brain injury

作者：Huang, Min[1];Zhang, Yong[1];Shen, Yanyang[1];Xu, Yiqin[1];Liu, Xuehong[1]

机构：[1]Shaoxing Univ, Sch Med, Dept Histol & Embryol, Shaoxing, Zhejiang, Peoples R China

年份：2025

卷号：134

外文期刊名：MOLECULAR AND CELLULAR NEUROSCIENCE

收录：SCI-EXPANDED(收录号：WOS:001510120100002)、、Scopus(收录号：2-s2.0-105007755374)、WOS

语种：英文

外文关键词：Stem cells; Apelin; Traumatic brain injury; Therapy

外文摘要：Traumatic brain injury (TBI) is one of the most serious neurological diseases worldwide. At present, there is no effective treatment for TBI. The regenerative effects of adipose-derived mesenchymal stem cells (ADSCs) on neuronal injury have garnered considerable concern in the scientific community over the past decade. Apelin-13, a key member of the apelin family, has anti-apoptotic, anti-inflammatory, and antioxidative stress effects. ADSCs can modify the microenvironment to enhance neuronal survival through secreting regulatory factors. Apelin-13 can regulate the microenvironment of ADSC differentiation to promote the growth and differentiation of ADSCs. This review delves into ADSCs' therapeutic potential in brain injury pathogenesis, explores apelin-13 protective mechanism against neurological damage, and analyzes how apelin-13 regulates ADSCs to achieve the modulatory effect on neurological recovery.