文献类型：期刊文献

英文题名：A Microwave-Promoted/Assisted Method for Rapid Preparation of Biaryl Seven-membered Lactones

作者：Hu, Chunqi[3];Li, Jun[1,2];Du, Wenting[1,2]

机构：[1]Hangzhou Med Coll, Dept Pharm, 481 Binwen Rd, Hangzhou 310053, Zhejiang, Peoples R China;[2]Wenzhou Med Univ, Wenzhou 325035, Peoples R China;[3]Shaoxing Univ, Coll Chem & Chem Engn, Shaoxing 312000, Peoples R China

年份：2017

卷号：13

期号：3

起止页码：301

外文期刊名：MEDICINAL CHEMISTRY

收录：SCI-EXPANDED(收录号：WOS:000402477800010)、、Scopus(收录号：2-s2.0-85019761739)、WOS

基金：This study was financially supported by Zhejiang Provincial Natural Science Foundation (No. LY16H300004), the Natural Science Foundation of China (No. 81502926 and 21002026) and the Education Department of Zhejiang Province, and the general research project (No. Y201431886). We are also grateful to the support provided by Zhejiang Provincial Program for the Cultivation of High-level Innovative Health Talents (2014) and The 151 Talents Project in new century in Zhejiang Province (the third level, 2011).

语种：英文

外文关键词：BSLs; carbene salt; lactones; N-heterocyclic carbine; microwave; umpolung reaction

外文摘要：Background: Biaryl seven-membered lactones (BSLs), the target compounds are a class of bioactive compounds with anti-arrhythmic activity, which also serve as a starting material or structural units for chemical synthesis. Objective: To report a simple and efficient procedure for the synthesis of biaryl seven-membered lactones. Method: Under microwave, the umpolung reaction was promoted by N-heterocyclic carbenes under oxygen, with anhydrous potassium carbonate as base and with 1,4,7,10,13,16-Hexanoxacyclooctadecane (18-crown-6) as a phase-transfer catalyst. Results: The practical protocol was found to be compatible with different structurally diverse substrates and with moderate to excellent yields. Conclusion: This synthesis method has the advantage of high efficacy and novelty, short reaction time, operation simplicity, mild condition and high yields, providing a useful and atom-economic approach to the synthesis of BSLs.