文献类型：期刊文献

英文题名：Therapeutic Effect of Curcumin and Methylprednisolone in the Rat Spinal Cord Injury

作者：Liu, Xuehong[1,2];Zhang, Yong[1];Yang, Yang[2];Lin, Jingquan[1];Huo, Xue[2];Du, Xiaoxue[2];Botchway, Benson O. A.[2];Fang, Marong[2]

机构：[1]Shaoxing Univ, Dept Histol & Embryol, Sch Med, Shaoxing City, Zhejiang, Peoples R China;[2]Zhejiang Univ, Inst Neurosci, Sch Med, 866 Yuhangtang Rd, Hangzhou 310058, Zhejiang, Peoples R China

年份：2018

卷号：301

期号：4

起止页码：686

外文期刊名：ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY

收录：SCI-EXPANDED(收录号：WOS:000427069100010)、、Scopus(收录号：2-s2.0-85035227827)、WOS

基金：Grant sponsor: Zhejiang Provincial Natural Science Founda- tion of China, Grant Number: LY15H170001; Grant sponsor: the National Natural Science Foundation of China, Grant Number: No. 81271355; and Grant sponsor: the Public Technology Applied Research Projects Foundation of Shaoxing City, Grant Number: No. 2015B70040.

语种：英文

外文关键词：spinal cord injury; curcumin; methylprednisolone

外文摘要：In addition to imperiling an individual's daily life, spinal cord injury (SCI), a catastrophic medical damage, can permanently impair an individual's body function. Methylprednisolone (MP), a medically accepted therapeutic drug for SCI, is highly controversial for the lack of consensus on its true therapeutic effect. In recent years, curcumin has served as a potential and novel therapeutic drug in SCI. Our study was intended to investigate the precise effect of MP and curcumin in SCI. We examined the function of MP and curcumin in a SCI model rat, both in vivo and in vitro, and found that there was a momentous improvement in Basso-Beattie-Bresnahan scores in the MP-treated group when compared with Cur-treated group within 14 days. Results obtained from the histological, immunohistochemistry and ultrastructural examinations evidenced the curative effect of MP was better than curcumin before Day 14. Nonetheless, there was a significant variation in the treatment effect between the MP-treated and Cur-treated groups after 14 days. The curcumin's effectiveness was more obvious than MP after 14 days following SCI. As such, we surmise that curcumin has a better therapeutic potential than MP with a prolong treatment time in the wake of SCI. Anat Rec, 301:686-696, 2018. (c) 2017 Wiley Periodicals, Inc.