文献类型：期刊文献

英文题名：Resveratrol can inhibit Notch signaling pathway to improve spinal cord injury

作者：Zhang, Songou[1];Botchway, Benson O. A.[2];Zhang, Yong[1];Liu, Xuehong[1]

机构：[1]Shaoxing Univ, Med Coll, Dept Histol & Embryol, Shaoxing 312000, Zhejiang, Peoples R China;[2]Zhejiang Univ, Sch Med, Inst Neurosci, Hangzhou, Zhejiang, Peoples R China

年份：2019

卷号：223

起止页码：100

外文期刊名：ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER

收录：SCI-EXPANDED(收录号：WOS:000469307300011)、、Scopus(收录号：2-s2.0-85062235357)、WOS

基金：This work was supported by the Natural Science Foundation of Zhejiang Province (no. LY19H170001) and Public Technology Applied Research Projects Foundation of Shaoxing City (no. 2017670066).

语种：英文

外文关键词：Resveratrol; Neuronal cell differentiation; Notch signaling pathway; Spinal cord injury; Neuroinflammation; Axonal regeneration

外文摘要：Spinal cord injury (SCI) is one of the severe central nervous system (CNS) diseases. Although various therapeutic approaches have been researched, there are still no effective therapeutic measures for SCI. Development of novel, safe and effective therapeutics for SCI have currently gained a lot of interest. Medicinal and chemical agents have the tendency of regulating signaling pathways. Notch signaling pathway plays an important role in neuronal cell differentiation, neuroinflammation and axonal regeneration in the wake of SCI. Resveratrol has been reported to exert neuroprotective effects in CNS conditions. Resveratrol can inhibit Notch signaling pathway to curtail SCI. Herein, we systematically review potential mechanisms of resveratrol-inhibiting Notch signaling pathway in SCI treatment. (C) 2019 Published by Elsevier GmbH.