文献类型：期刊文献

英文题名：A New (3,6)-Connected Heterometallic Coordination Polymer: Therapeutic and Protective Effect on Ischemic Cerebral Infarction

作者：Ma, Jia[1];Wang, Jianer[2];He, Yuping[3];Huang, Yiwei[3];Chen, Yejun[3]

机构：[1]Ningbo Yinzhou 2 Hosp, Dept Neurol, Ningbo, Zhejiang, Peoples R China;[2]Yuhang Dist Second Peoples Hosp, Dept Neurol, Hangzhou, Zhejiang, Peoples R China;[3]Shaoxing Univ, Dept Neurol, Zhuji Affiliated Hosp, Zhuji, Zhejiang, Peoples R China

年份：2021

卷号：2021

外文期刊名：JOURNAL OF CHEMISTRY

收录：SCI-EXPANDED(收录号：WOS:000717583900005)、、Scopus(收录号：2-s2.0-85118950155)、WOS

基金：The research was supported by the Clinical Research Fund of Zhejiang Medical Association (2018ZYC-A111).

语种：英文

外文摘要：Solvothermal reaction of 4,4',4'-nitrilotribenzoic acid (H(3)TCA) with Ca(NO3)(2)center dot 4H(2)O and Cd(NO3)(2)center dot 4H(2)O successfully afforded a heterometallic compound, that is, [Cd2Ca(TCA)(2)(DMA)(2)(H2O)(3)](n)center dot 2n(DMA) (1, DMA = N,N'-dimethylacetamide). The structure of 1 was further characterized through EA, diffraction of single crystal X-ray, and thermogravimetric analysis (TGA) together with powder X-ray diffraction (PXRD). Moreover, complex 1's luminescent performance in solid state was also discussed at environmental temperature. The applications on the ischemic cerebral infarction therapy were evaluated, and the specific mechanism was investigated at the same time. Firstly, the hypersensitivity C-reactive protein (hs-CRP) content in human brain microvascular endothelial cell (HBMEC) was measured with real-time reverse transcription-polymerase chain reaction (RT-PCR). Then, interleukin-18 and interleukin-1 beta content released through the HBMEC was detected with enzyme-linked immunosorbent assay (ELISA).