文献类型：期刊文献

英文题名：Molecular Immune Mechanism of Intestinal Microbiota and Their Metabolites in the Occurrence and Development of Liver Cancer

作者：Bi, Chenchen[1];Xiao, Geqiong[2];Liu, Chunyan[3];Yan, Junwei[1];Chen, Jiaqi[1];Si, Wenzhang[4];Zhang, Jian[1];Liu, Zheng[1]

机构：[1]Shaoxing Univ, Med Coll, Dept Pharmacol, Shaoxing, Peoples R China;[2]Shaoxing Univ, Affiliated Hosp, Dept Oncol, Shaoxing, Peoples R China;[3]Shaoxing Peoples Hosp, Dept Clin Med, Shaoxing, Peoples R China;[4]Shaoxing Univ, Dept Gen Surg, Affiliated Hosp, Shaoxing, Peoples R China

年份：2021

卷号：9

外文期刊名：FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY

收录：SCI-EXPANDED(收录号：WOS:000732818900001)、、Scopus(收录号：2-s2.0-85121744693)、WOS

基金：Funding This work was funded by the Public Welfare Technology Applied Research Projects in Zhejiang Province (No. 2016C33191) and the Science and Technology Planning Project of Shaoxing City, China (Nos. 2017B70050 and 2020A13061).

语种：英文

外文关键词：intestinal flora; metabolites; liver cancer; occurrence and development; immune mechanism; therapeutics

外文摘要：Intestinal microorganisms are closely associated with immunity, metabolism, and inflammation, and play an important role in health and diseases such as inflammatory bowel disease, diabetes, cardiovascular disease, Parkinson's disease, and cancer. Liver cancer is one of the most fatal cancers in humans. Most of liver cancers are slowly transformed from viral hepatitis, alcoholic liver disease, and non-alcoholic fatty liver disease. However, the relationship between intestinal microbiota and their metabolites, including short-chain fatty acids, bile acids, indoles, and ethanol, and liver cancer remains unclear. Here, we summarize the molecular immune mechanism of intestinal microbiota and their metabolites in the occurrence and development of liver cancer and reveal the important role of the microbiota-gut-liver axis in liver cancer. In addition, we describe how the intestinal flora can be balanced by antibiotics, probiotics, postbiotics, and fecal bacteria transplantation to improve the treatment of liver cancer. This review describes the immunomolecular mechanism of intestinal microbiota and their metabolites in the occurrence and development of hepatic cancer and provides theoretical evidence support for future clinical practice.