文献类型：期刊文献

中文题名：子午流注择时耳穴贴压法联合升阳益胃汤治疗慢性萎缩性胃炎临床研究

英文题名：Clinical Study on Timing Auricular Point Sticking Therapy Based on the Ebb and Flow of Midnight and Midday Combined with Shengyang Yiwei Tang for Chronic Atrophic Gastritis

作者：李莉[1];陈俊寅[2];胡玲琴[1];卢珊珊[1];吕秋琼[3];尉理梁[4]

机构：[1]绍兴文理学院附属医院老年医学科,浙江绍兴312000;[2]绍兴文理学院附属医院消化内科,浙江绍兴312000;[3]绍兴文理学院附属医院检验科,浙江绍兴312000;[4]绍兴文理学院附属医院中医科,浙江绍兴312000

年份：2022

卷号：54

期号：19

起止页码：204

中文期刊名：新中医

外文期刊名：New Chinese Medicine

语种：中文

中文关键词：慢性萎缩性胃炎;子午流注;耳穴贴压;升阳益胃汤

外文关键词：Chronic atrophic gastritis;The ebb and flow of midnight and midday;Auricular point sticking therapy;Shengyang Yiwei tang

中文摘要：目的:观察子午流注择时耳穴贴压法联合升阳益胃汤治疗慢性萎缩性胃炎(CAG)的临床疗效。方法:按就诊先后顺序将80例CAG患者分为观察组与对照组各40例。对照组给予升阳益胃汤治疗,观察组给予升阳益胃汤联合子午流注择时耳穴贴压法治疗。比较2组治疗前后中医证候积分、内镜病理积分、胃蛋白酶原、免疫炎性指标及miR-26a、miR-32表达,并评价2组临床疗效及不良反应发生情况。结果:观察组中医证候疗效、内镜病理疗效的总有效率高于对照组(P<0.05)。治疗2周、4周后,2组中医证候积分、内镜病理积分、胃蛋白酶原Ⅰ(PGⅠ)、胃蛋白酶原Ⅱ(PGⅡ)、白细胞介素-2 (IL-2)、白细胞介素-6 (IL-6)、肿瘤坏死因子-α (TNF-α)水平均较治疗前降低(P<0.05),且观察组治疗2周、4周后上述指标改善优于对照组(P<0.05)。治疗2周后、4周后,2组miR-26a表达升高(P<0.05),miR-32表达降低(P<0.05),2组比较,差异无统计学意义(P>0.05)。2组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:子午流注择时耳穴贴压法联合升阳益胃汤治疗CAG疗效确切,能有效降低患者胃蛋白酶原水平,减轻炎性反应,调节miR-26a、miR-32表达,安全性较高。

外文摘要：Objective:To observe the clinical effect of timing auricular point sticking therapy based on the ebb and flow of midnight and midday combined with Shengyang Yiwei tang for chronic atrophic gastritis(CAG). Methods: A total of 80 cases of CAG patients were divided into the observation group and the control group according to the order of treatment, with 40 cases in each group. The control group was treated with Shengyang Yiwei tang, and the observation group was treated with Shengyang Yiwei tang combined with timing auricular point sticking therapy based on the ebb and flow of midnight and midday.Before and after treatment, Chinese medicine syndrome scores, endoscopic pathological scores,pepsinogen,immune inflammatory indexes and expressions of miR-26a and miR-32 in the two groups were compared. The clinical effects and the incidence of adverse reactions in the two groups were evaluated. Results:The total effective rates of Chinese medicine syndromes and endoscopic pathology in the observation group were higher than those in the control group(P<0.05). After two and four weeks of treatment, the Chinese medicine syndrome scores, the endoscopic pathological scores, the levels of pepsinogen Ⅰ(PGⅠ),pepsinogen Ⅱ(PGⅡ),interleukin-2(IL-2),interleukin-6(IL-6) and tumor necrosis factor-α(TNF-α), in the two groups were decreased when compared with those before treatment(P<0.05), and the improvement of the above indexes in the observation group was better than that in the control group(P<0.05). After two and four weeks of treatment,the miR-26a expressions in the two groups were increased, the miR-32 expressions were decreased(P<0.05), and there being no significant difference being found in the comparison between the two groups(P>0.05). There was no significant difference being found in the comparison of the incidence of adverse reactions between the two groups(P>0.05). Conclusion: Timing Auricular point sticking therapy based on the ebb and flow of midnight and midday combined with Shengyang Yiwei tang has a definite curative effect in treating CAG, which can effectively reduce levels of pepsinogen,relieve inflammatory responses,and regulate the expressions of miR-26a and miR-32 with high safety.