文献类型：期刊文献

英文题名：Synthesis and Antimicrobial Activities of Oxazepine and Oxazocine Derivatives

作者：Tang, Ran[1,2];Jiang, Yu-liang[1];Wang, Bing-xiang[1];Shen, Yong-miao[2]

机构：[1]Nanjing Normal Univ, Sch Chem & Mat Sci, Jiangsu Key Lab Biofunct Mat, Nanjing 210097, Jiangsu, Peoples R China;[2]Shaoxing Univ, Dept Chem & Chem Engn, Shaoxing 312000, Peoples R China

年份：2014

卷号：69

期号：7-8

起止页码：283

外文期刊名：ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES

收录：SCI-EXPANDED(收录号：WOS:000343191800003)、、Scopus(收录号：2-s2.0-84907313237)、WOS

基金：This work was supported by the National Natural Science Foundation of China (NSFC 21202101) and Key Laboratory for Advanced Technology in Environmental Protection of Jiangsu Province (AE201306).

语种：英文

外文关键词：Oxazepine; Oxazocine; Antimicrobial Activity; Structure-Activity Relationship

外文摘要：A series of annulated 7-membered oxazepine and 8-membered oxazocine derivatives were synthesized by photoreaction of phthalimide derivatives and an alkene. The antimicrobial activities of the synthesized compounds were evaluated, and compounds 18 and 20 exhibited best antibacterial activity against Gram-positive bacteria. The relationships between structure (especially steric structure) and antimicrobial activities are discussed.