文献类型：期刊文献

英文题名：Role of the microbiota-gut-heart axis between bile acids and cardiovascular disease

作者：Zhang, Ziyi[1,2];Lv, Tingting[2,3];Wang, Xiang[2];Wu, Menglu[2];Zhang, Ruolin[2];Yang, Xiaopeng[2];Fu, Yongping[1,2,4];Liu, Zheng[2,5]

机构：[1]Shaoxing Univ, Affiliated Hosp, Dept Cardiovasc Med, Shaoxing, Zhejiang, Peoples R China;[2]Shaoxing Univ, Sch Med, Dept Pharmacol, Shaoxing, Zhejiang, Peoples R China;[3]Zhejiang Univ, Sch Med, Shaoxing Hosp, Shaoxing Peoples Hosp,Dept Cardiol, Shaoxing, Zhejiang, Peoples R China;[4]999 Zhongxing South Rd, Shaoxing 312000, Peoples R China;[5]900 Chengnan Ave, Shaoxing 312000, Peoples R China

年份：2024

卷号：174

外文期刊名：BIOMEDICINE & PHARMACOTHERAPY

收录：SCI-EXPANDED(收录号：WOS:001224231000001)、、Scopus(收录号：2-s2.0-85189429825)、WOS

基金：This work was funded by the Natural Science Foundation of Zhejiang Province (No. LY18H020008) , the Medical Science and Technology Foundation of Zhejiang Province (No. 2019RC297) , and the Shaoxing Science and Technology Project (No. 2018C30029) . We would like to thank LetPub ( www.letpub.com ) for its linguistic assistance during the preparation of this manuscript. All the images in this article were created using Figdraw.

语种：英文

外文关键词：Bile acids; Cardiovascular disease; Microbiota-gut-heart axis; Therapeutic strategy

外文摘要：Bile acid (BA) receptors (e.g., farnesoid X-activated receptor, muscarinic receptor) are expressed in cardiomyocytes, endothelial cells, and vascular smooth muscle cells, indicating the relevance of BAs to cardiovascular disease (CVD). Hydrophobic BAs are cardiotoxic, while hydrophilic BAs are cardioprotective. For example, fetal cardiac insufficiency in maternal intrahepatic cholestasis during pregnancy, and the degree of fetal cardiac abnormality, is closely related to the level of hydrophobic BAs in maternal blood and infant blood. However, ursodeoxycholic acid (the most hydrophilic BA) can reverse/prevent these detrimental effects of increased levels of hydrophobic BAs on the heart. The gut microbiota (GM) and GM metabolites (especially secondary BAs) have crucial roles in hypertension, atherosclerosis, unstable angina, and heart failure. Herein, we describe the relationship between CVD and the GM at the BA level. We combine the concept of the "microbiota-gut-heart axis" (MGHA) and postulate the role and mechanism of BAs in CVD development. In addition, the strategies for treating CVD with BAs under the MGHA are proposed.