文献类型：期刊文献

中文题名：左西孟旦联合沙库巴曲缬沙坦治疗老年难治性心力衰竭的疗效

英文题名：Efficacy of levosimendan combined with sacubitril and valsartan in the treatment of senile refractory heart failure

作者：金志江[1];傅永平[1];刘龙斌[1];铁春苗[1];何苏利[1];胡佳峰[1]

机构：[1]绍兴文理学院附属医院心内科,浙江绍兴312000

年份：2021

卷号：59

期号：25

起止页码：47

中文期刊名：中国现代医生

外文期刊名：China Modern Doctor

基金：浙江省医药卫生科技计划项目(2018KY842)。

语种：中文

中文关键词：左西孟旦;沙库巴曲缬沙坦;老年难治性心力衰竭;疗效

外文关键词：Levosimendan;Sacubitril valsartan;Elderly refractory heart failure;Efficacy

中文摘要：目的 探讨左西孟旦联合沙库巴曲缬沙坦治疗老年难治性心力衰竭的疗效。方法 选取2019年1—12月在我院心内科住院的老年难治性心力衰竭患者共62例,随机分为观察组和对照组,每组各31例。两组均用利尿剂常规治疗。观察组加用左西孟旦和沙库巴曲缬沙坦治疗,对照组加用多巴酚丁胺和缬沙坦治疗,统计分析出院时临床症状、住院时间及治疗前后3个月两组6 min步行试验(6 MWT)、左室舒张期内径(LVEDD)、左室射血分数(LVEF)及脑钠肽前体(pro-BNP)等,并对疗效进行评价。结果 观察组的总有效率高于对照组(71.0%vs.58.1%),差异有统计学意义(P<0.05)。观察组住院时间为(10±2)d,明显短于对照组的(15±3)d,差异有统计学意义(P<0.05)。治疗3个月后,两组6 MWT较治疗前明显延长,LVEF较治疗前明显升高,LVEDD、pro-BNP较治疗前明显降低,且观察组变化幅度高于对照组,差异有统计学意义(P<0.05)。结论 左西孟旦联合沙库巴曲缬沙坦治疗老年性难治性心力衰竭疗效肯定,能改善患者的心脏功能及预后。

外文摘要：Objective To investigate levosimendan combined with sacubitril and valsartan in the treatment of senile refractory heart failure.Methods A total of 62 elderly patients with refractory heart failure in Department of Cardiology in our hospital from January to December 2019 were enrolled,with 31 cases in each group.They were randomly divided into the observation group and the control group.Both groups were treated with diuretics routinely.The observation group was treated with levosimendan combined with sacubatril and valsartan.The control group was treated with dobutamine and valsartan.The clinical symptoms at the time of discharge,the length of hospital stay,6 minutes walk test(6MWT),left ventricular intradiastolic diameter(LVEDD),left ventricular ejection fraction(LVEF)and brain natriuretic peptide(pro-BNP)at the three months before and after treatment were statistically analyzed in both groups.The efficacy was evaluated.Results After treatment,the total effectiveness in the observation group was higher than that in the control group(71.0%vs.58.1%),with significant difference(P<0.05).The hospital stay in the observation group was(10±2)d,which was shorter than that of(15±3)d in the control group,with significant difference(P<0.05).After treatment of 3 months,the 6MWT between the two groups was longer than that before treatment,LVEF was higher than that before treatment,LVEDD and pro-BNP were significantly lower than those before treatment,and the changes of 6MWT,LVEDD,LVEF and pro-BNP in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).Conclusion Levosimendan combined with sacubatril and valsartan in the treatment of senile refractory heart failure has a positive curative effect,and it can improve the heart function and prognosis of patients.