文献类型：期刊文献

中文题名：乳腺癌保乳患者术后医院感染病原学特点及血清炎症因子和bFGF表达分析

英文题名：Etiological characteristics of postoperative nosocomial infection in breast cancer patients undergoing breast conserving surgery and expression of serum inflammatory factors and bFGF

作者：金冬春[1];裴俊烽[1];缪炳良[1];张前进[1];李达[1]

机构：[1]绍兴文理学院附属医院肿瘤科

年份：2019

卷号：0

期号：9

起止页码：1404

中文期刊名：中华医院感染学杂志

外文期刊名：Chinese Journal of Nosocomiology

收录：CSTPCD、、北大核心2017、CSCD_E2019_2020、北大核心、CSCD

基金：浙江省医药卫生一般研究计划基金资助项目(2014KYA176)

语种：中文

中文关键词：乳腺癌;保乳手术;术后医院感染;病原学;C-反应蛋白;白介素-6;降钙素原;碱性成纤维细胞生长因子

外文关键词：Breast cancer;Breast conserving surgery;Postoperative nosocomial infection;Etiology;C-reactive protein;Interleukin-6;Procalcitonin;Basic fibroblast growth factor

中文摘要：目的探讨乳腺癌保乳手术患者术后医院感染病原学特点及血清炎症因子C-反应蛋白(CRP)、白介素-6(IL-6)和降钙素原(PCT)与碱性成纤维细胞生长因子(bFGF)的变化。方法选择医院2016年1月-2018年1月收治的行保乳手术乳腺癌患者394例为研究对象,统计患者医院感染发生情况,分析医院感染患者病原菌的分布特点,采用酶联免疫吸附法测定患者血清CRP、IL-6、PCT和bFGF水平。结果乳腺癌保乳手术394例患者,发生术后医院感染38例,感染率为9.64%。术后医院感染以呼吸道和切口为主,分别占44.74%和36.84%。38例术后感染患者临床样本共分离病原菌51株,革兰阴性菌28株(54.90%),以铜绿假单胞菌和大肠埃希菌为主,革兰阳性菌21株(41.18%),以金黄色葡萄球菌为主。术后医院感染患者血清CRP、IL-6、PCT和bFGF指标水平均高于未感染患者(P<0.05)。结论乳腺癌保乳手术术后医院感染患者分离的病原菌,以革兰阴性菌为主,要加强无菌操作且按照耐药性合理使用抗菌药物,且保乳术后医院感染患者血清CRP、IL-6、PCT和bFGF含量水平均升高。

外文摘要：OBJECTIVE To explore the etiological characteristics of postoperative nosocomial infection in the breast cancer patients undergoing breast conserving surgery and observe the changes of serum inflammatory factors C-reactive protein(CRP),interleukin-6(IL-6),procalcitonin(PCT)and basic fibroblast growth factor(bFGF).METHODS A total of 394 breast cancer patients who received breast conserving surgery in the hospital from Jan2016 to Jan 2018 were recruited as the study objects,the incidence of nosocomial infection was statistically analyzed,the distribution of the pathogens causing the nosocomial infection was analyzed,and the levels of serum CRP,IL-6,PCT and bFGF were determined by means of enzyme-linked immunosorbent assay.RESULTS Of the394 patients who received the breast conserving surgery,38 had postoperative nosocomial infection,with the infection rate 9.64%,44.74%of whom had respiratory tract infection,and 36.84%had incision infection.Totally 51 strains of pathogens were isolated from clinical specimens of the 38 patients with postoperative nosocomial infection,28(54.90%)of which were gram-negative bacteria,21(41.18%)were gram-positive bacteria;Pseudomonas aeruginosa and Escherichia coli were the predominant species of the gram-negative bacteria;Staphylococcus aureus was dominant among the gram-positive bacteria.The levels of serum CRP,IL-6,PCT and bFGF of the patients with postoperative nosocomial infection were significantly higher than those of the patients without infection(P<0.05).CONCLUSION The gram-negative bacteria are dominant among the pathogens that are isolated from the breast cancer patients after the breast conserving surgery.It is necessary to strengthen the aseptic operation and reasonably use antibiotics based on the result of drug susceptibility testing.The levels of serum CRP,IL-6,PCT and bFGF of the breast conserving surgery patients with postoperative nosocomial infection are elevated.