文献类型：期刊文献

英文题名：Practical Synthesis of epsilon-Carotene

作者：Wu, Chunlei[1];Cao, Ruiwei[2];Song, Xiaohua[1];Lv, Chunlei[2];Ye, Weidong[2];Pi, Shiqing[2];Chen, Chaohui[2];Shen, Runpu[1]

机构：[1]Shaoxing Univ, Dept Chem & Chem Engn, Shaoxing 312000, Zhejiang, Peoples R China;[2]Zhejiang Med Co Ltd, Xinchang 312500, Zhejiang, Peoples R China

年份：2015

卷号：47

期号：4

起止页码：481

外文期刊名：SYNTHESIS-STUTTGART

收录：SCI-EXPANDED(收录号：WOS:000350219700004)、、EI(收录号：20150600496200)、Scopus(收录号：2-s2.0-84961363649)、WOS、CCR-EXPANDED(收录号：WOS:000350219700004)

基金：We acknowledge the National Natural Science Foundation of China (No. 21176156 and No. 81202411) and Research Fund of Zhejiang Educational Committee of China (Y 201431839).

语种：英文

外文关键词：total synthesis; Wittig reactions; carotenes; isomerizations

外文摘要：A novel route for the total synthesis of epsilon-carotene is described. The synthesis is based on a condensation between alpha-cyclocitral and diethyl [(2E)-3-methoxy-2-methylprop-2-en-1-yl] phosphonate to give a C-14 enol ether, hydrolysis of the C-14-enol ether to a give a C-14 aldehyde, and a modified Wittig-Horner reaction of the C-15 phosphonate from the C-14 aldehyde and a C-10 triene dialdehyde to give epsilon-carotene. The synthetic steps are easily performed and are practical for largescale production.