文献类型：期刊文献

中文题名：Cx43和Pax3在人胚胎早期小肠肌层中的表达及其意义

英文题名：Expression of Cx43 and Pax3 in the small intestinal muscular layers of early human embryos

作者：刘学红[1];张金萍[1];何淑英[2];宋文芳[2]

机构：[1]绍兴文理学院医学院组织学与胚胎学教研室,浙江绍兴312000;[2]绍兴市计划生育技术指导站,浙江绍兴312000

年份：2008

卷号：28

期号：4

起止页码：634

中文期刊名：南方医科大学学报

外文期刊名：Journal of Southern Medical University

收录：MEDLINE(收录号：18495608)、CSTPCD、、北大核心2004、Scopus(收录号：2-s2.0-63149096836)、CSCD2011_2012、北大核心、CSCD、PubMed

语种：中文

中文关键词：小肠;Cx43蛋白;Pax3蛋白;人胚胎

外文关键词：small intestines; Cx43 protein; Pax3 protein; human embryos

中文摘要：目的探讨Cx43和Pax3蛋白在人胚胎早期小肠肌层组织中的表达规律。方法应用免疫组织化学SABC法检测第2、3、4三个月龄段,Cx43和Pax3蛋白在人胚胎小肠肌层组织中的表达。结果第2月胚龄时,Cx43和Pax3在小肠肌层组织中均呈阴性表达。第3个月胎龄段,Cx43和Pax3在小肠内环肌层细胞呈阴性表达,外纵肌层部分细胞呈阳性表达,肌间神经丛部分细胞呈阳性表达。第4个月胎龄段,Cx43和Pax3在小肠内环肌、外纵肌层和肌间神经丛均有细胞呈阳性表达。结论Cx43和Pax3蛋白与人胚胎早期小肠肌层组织细胞的生长发育关系密切。

外文摘要：Objective To explore the patterns of Cx43 and Pax3 protein expressions in the small intestinal muscular layers of human embryo during early development. Methods Immunohistochemistry with SABC method was employed to examine the expression of Cx43 and Pax3 proteins in the muscular layers of the small intestine in early human embryos in the second to fourth months of gestation. Results In the second month of gestation, the muscle layer of the small intestine was negative lor Cx43 and Pax3 protein expressions. In the third month, Cx43 and Pax3 expressions were negative in the inner circular muscle layer, but some positive cells were found in the longitudinal muscle layer and the myenteric plexus, In the fourth month, positive expression of Cx43 and Pax3 proteins were seen in the entire muscle layer. Conclusion Cx43 and Pax3 proteins are closely related to the growth and development of the cells and tissues in the small intestinal muscle layer in human embryos.