文献类型：期刊文献

英文题名：Quercetin Can Improve Spinal Cord Injury by Regulating the mTOR Signaling Pathway

作者：Wang, Xichen[1];Fu, Yuke[1];Botchway, Benson O. A.[2];Zhang, Yufeng[1];Zhang, Yong[1];Jin, Tian[1];Liu, Xuehong[1]

机构：[1]Shaoxing Univ, Sch Med, Dept Histol & Embryol, Shaoxing, Zhejiang, Peoples R China;[2]Zhejiang Univ, Inst Neurosci, Sch Med, Hangzhou, Peoples R China

年份：2022

卷号：13

外文期刊名：FRONTIERS IN NEUROLOGY

收录：SCI-EXPANDED(收录号：WOS:000806050000001)、、Scopus(收录号：2-s2.0-85131748141)、WOS

基金：Funding This study was supported by the Natural Science Foundation of Zhejiang Province (No. LY19H170001).

语种：英文

外文关键词：quercetin; mTOR signaling pathway; spinal cord injury; inflammation; apoptosis; autophagy mTOR signaling pathway; autophagy

外文摘要：The pathogenesis of spinal cord injury (SCI) is complex. At present, there is no effective treatment for SCI, with most current interventions focused on improving the symptoms. Inflammation, apoptosis, autophagy, and oxidative stress caused by secondary SCI may instigate serious consequences in the event of SCI. The mammalian target of rapamycin (mTOR), as a key signaling molecule, participates in the regulation of inflammation, apoptosis, and autophagy in several processes associated with SCI. Quercetin can reduce the loss of myelin sheath, enhance the ability of antioxidant stress, and promote axonal regeneration. Moreover, quercetin is also a significant player in regulating the mTOR signaling pathway that improves pathological alterations following neuronal injury. Herein, we review the therapeutic effects of quercetin in SCI through its modulation of the mTOR signaling pathway and elaborate on how it can be a potential interventional agent for SCI.