文献类型：期刊文献

英文题名：Generation of Carbamoyl Radicals and 3,4-Dihydroquinolin-2(1H )-ones Enabled by Iron Photoredox Catalysis

作者：Fu, Yanhua[1];Zhang, Chao[1];Cai, Tao[2];Feng, Gaofeng[1]

机构：[1]Shaoxing Univ, Zhejiang Key Lab Alternat Technol Fine Chem Proc, Shaoxing 312000, Peoples R China;[2]Shaoxing Univ, Coll Chem & Chem Engn, Shaoxing 312000, Peoples R China

年份：2024

外文期刊名：SYNLETT

收录：SCI-EXPANDED(收录号：WOS:001224518500002)、、WOS

基金：We thank Professor Jian Jin (Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences) for discussions and help.

语种：英文

外文关键词：iron catalysis; photoredox catalysis; dihydroquinolinones; carbamoyl radicals; oxamic acids

外文摘要：A new protocol for accessing 3,4-dihydroquinolin-2(1H)-ones was established through a sequence of iron-catalyzed photoredox generation of carbamoyl radicals from oxamic acids, addition of the carbamoyl radicals to electron-deficient alkenes, intramolecular cyclization, and aromatization. The process is compatible with a variety of N-phenyloxamic acids and monosubstituted, 1,1-disubstituted, and trisubstituted electron-deficient alkenes. Employing cheap, readily available, and environmentally benign iron as the catalyst, the protocol provides an excellent alternative for synthesis of 3,4-dihydroquinolin-2(1H)-ones.