文献类型：期刊文献

英文题名：Electrochemical activation and renewal of pyrrole nitrogen sites in porphyrin-based conjugated polymer for simultaneous determination of uric acid and adrenaline

作者：Liu, Xiaoya[1];Ji, Hepeng[1];Tang, Junyan[1];Tao, Feifei[2];Zhang, Xicheng[1];Yao, Zhengrong[1];Song, Hongchen[3];Li, Caolong[1,4];Wang, Fei[1]

机构：[1]China Pharmaceut Univ, Sch Sci, Key Lab Biomed Funct Mat, Nanjing 211198, Peoples R China;[2]Shaoxing Univ, Dept Chem & Chem Engn, Shaoxing 312000, Peoples R China;[3]Chinese Acad Sci, Guangzhou Inst Adv Technol, Guangdong Key Lab Membrane Mat & Membrane Separat, Guangzhou 511458, Peoples R China;[4]Tibetan Tradit Med Coll, Tibetan Med Res Inst, Tibet 850000, Peoples R China

年份：2021

卷号：884

外文期刊名：JOURNAL OF ELECTROANALYTICAL CHEMISTRY

收录：SCI-EXPANDED(收录号：WOS:000633375700010)、、EI(收录号：20210909997909)、Scopus(收录号：2-s2.0-85101564481)、WOS

基金：We appreciate the financial support by the National Key Research and Development Program (2019YFC0312602), National Natural Science Foundation of China (81660708), Science and Technology Support Program of Jiangsu Province (BE2018389), Key Project of Tibetan Medical Administration of Tibet (2017005) as well as "Double First-Class" University Project (CPU2018GY25), National Key Research and Development Projects of China (2019YFC1711300).

语种：英文

外文关键词：Porphyrin-based conjugated polymers; Pyrrole N activation; ??? interaction; Renewable; Uric acid; Adrenaline

外文摘要：In this work, 5,10,15,20-tetrakis(4-ethynylphenyl) porphyrin-based conjugated polymer (P-TP) functionalized reduced graphene oxide (rGO), a renewable electrochemical sensor (P-TP/rGO), has been fabricated for the simultaneous determination of adrenaline (AD) and uric acid (UA). Herein, P-TP as a large ?-conjugated aromatic system could not only provide more appropriate recognition sites, but also increase the adsorption degree of phenol and aniline via ?-? interaction. Additionally, the involvement of alkyne bond within P-TP network could help improve the electron transfer efficiency in P-TP/rGO sensor due to its electron-adsorbing effect. Most importantly, activation of pyrrole N in porphyrin center by electrochemical reduction produces more catalytic sites and leads to higher electrochemical performance. The electrochemical results show that increasing the content of activated pyrrole N leads to higher catalytic activity, which suggesting that the activated pyrrole N can be responsible for the oxidation of AD and UA. Thus, our designed electrochemical sensor exhibits a sensitive response to AD and UA, with detection limits of 4.56 and 3.01 nM, respectively. Specially, after hundreds of successive determinations, the P-TP/rGO sensor can be renewed by a simple electrochemical reduction and maintain the satisfying repeatability, and reproducibility. This work also provides a helpful insight into effective activation and continuous renewing of porphyrin-based conjugated polymer in electrochemical bioanalysis.