文献类型：期刊文献

英文题名：Photo-Responsive Ovalbumin-Loaded MnO2 Nanoparticles for Enhanced T-1-Magnetic Resonance Imaging and Immunotherapy of Cancer

作者：Hou, Yike[1];Huang, Shuqi[1];Tang, Zhe[1];Yu, Zhangsen[2];Iqbal, Muhammad Zubair[1];Kong, Xiangdong[1]

机构：[1]Zhejiang Sci Tech Univ, Inst Smart Biomed Mat, Sch Mat Sci & Engn, Hangzhou 310018, Peoples R China;[2]Shaoxing Univ, Sch Med, Med Sci Res Ctr, Lab Nanomed, Shaoxing 312000, Zhejiang, Peoples R China

年份：2023

外文期刊名：PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION

收录：SCI-EXPANDED(收录号：WOS:001059122700001)、、WOS

基金：The authors acknowledge the support of the National Natural Science Foundation of China (51672250), and the Zhejiang International Science and Technology Cooperation Project (2021C01180 and 2019C04020), and the Research Foundation of ZSTU (LW-YP2022006).

语种：英文

外文关键词：antigen delivery; cancer immunotherapy; contrast agent; magnetic resonance imaging; ovalbumin

外文摘要：Photo-responsive combinational therapeutics attained significant attention in cancer theranostic owing to the versatile features of nanomaterials. The simplest nano-design with unique properties to carry out multifunctionalties is a challenging assignment. Herein, a facile solvothermal method is employed to fabricate homogeneous MnO2 sea urchin-shaped nanoparticles (MnO2-OVA NPs) with a high loading capacity (86.15%) of ovalbumin (OVA) antigen. The prepared MnO2-OVA NPs demonstrated excellent biocompatibility against different cell lines and significant cellular uptake, resulting in mature dendritic cells to enhance anti-tumor immunity. The synthesized sea urchin-shaped MnO2-OVA NPs further exhibited self-generated catalytic properties that efficiently relieve tumor hypoxia and improve cancer therapies. More excitingly, MnO2-OVA NPs endorsed reactive oxygen species (ROS) in response of minute UV irradiation (mW) for photodynamic therapy. Further, the prepared photo-responsive nanoparticles showed promising T1-MR imaging and relaxivity properties for diagnosis and real-time drug delivery monitoring. These synergetic therapeutic strategies produced by MnO2-OVA NPs showed excellency as a potential theranostic agent.