文献类型：期刊文献

英文题名：Curcumin can improve spinal cord injury by inhibiting DNA methylation

作者：Zhou, Yu[1];Zhang, Yong[1];Botchway, Benson O. A.[2,3];Wang, Xichen[1];Liu, Xuehong[1]

机构：[1]Shaoxing Univ, Med Coll, Dept Histol & Embryol, Shaoxing 312000, Zhejiang, Peoples R China;[2]Zhejiang Univ, Inst Neurosci, Sch Med, Hangzhou, Peoples R China;[3]Bupa Cromwell Hosp, London, England

年份：2023

外文期刊名：MOLECULAR AND CELLULAR BIOCHEMISTRY

收录：SCI-EXPANDED(收录号：WOS:000974969800004)、、Scopus(收录号：2-s2.0-85153083859)、WOS

基金：This work was supported by the Natural Science Foundation of Zhejiang Province (Grant No. LY19H170001).

语种：英文

外文关键词：DNA methylation; Spinal cord injury; Curcumin; Nuclear factor-kappa B; Pharmacological intervention

外文摘要：Spinal cord injury (SCI) is a serious central nervous system disease. Traumatic SCI often causes persistent neurological deficits below the injury level. Epigenetic changes occur after SCI. Studies have shown DNA methylation to be a key player in nerve regeneration and remodeling, and in regulating some pathophysiological characteristics of SCI. Curcumin is a natural polyphenol from turmeric. It has anti-inflammatory, antioxidant, and neuroprotective effects, and can mitigate the cell and tissue damage caused by SCI. This report analyzed the specific functions of DNA methylation in central nervous system diseases, especially traumatic brain injury and SCI. DNA methylation can regulate the level of gene expressions in the central nervous system. Therefore, pharmacological interventions regulating DNA methylation may be promising for SCI.