文献类型：期刊文献

中文题名：偏执型首发精神分裂症患者大脑左侧额叶CT值研究

英文题名：CT value changes in left frontal lobe of patients with paranoia first- episode schizophrenia

作者：程祖胜[1];夏国园[2];田国强[3];王爱芝[4];诸绍锋[1]

机构：[1]绍兴市第七人民医院放射科;[2]绍兴文理学院医学院;[3]绍兴市第七人民医院精神心理科;[4]绍兴市人民医院心内科

年份：2016

卷号：0

期号：13

起止页码：1086

中文期刊名：浙江医学

外文期刊名：Zhejiang Medical Journal

收录：CSTPCD

基金：绍兴文理学院医学院人才基金(2014-A2)

语种：中文

中文关键词：首发精神分裂症;偏执型;额叶;CT值

外文关键词：First-episode schizophrenia; Paranoia; Frontal lobe; CT value

中文摘要：目的探索偏执型首发精神分裂症(PFES)患者大脑左侧额叶CT值变化以及与临床资料的关系。方法选择200例经临床确诊的PFES患者资料,测量其脑部CT图像上大脑左侧额叶CT值,与同期180例正常志愿者进行比较,并分析PFES患者大脑左侧额叶CT值与临床资料的关系。结果 PFES患者大脑左侧额叶CT值为(34.12±1.45)HU,低于对照组的(38.36±1.26)HU,差异有统计学意义(P<0.01)。男、女性PFES患者大脑左侧额叶CT值分别为(34.13±1.18)、(33.96±1.51)HU,年龄≤30岁与>30岁PFES患者分别为(34.25±1.26)、(33.85±1.01)HU,差异均无统计学意义(均P>0.05);Pearson相关分析提示CT值与年龄无相关性(r=0.08,P>0.05)。不同受教育程度、PANSS分组、病程、居住环境和有无职业的PFES患者大脑左侧额叶CT值差异均无统计学意义(均P>0.05)。结论 PFES患者大脑左侧额叶CT值明显降低,支持PFES大脑偏侧性假说,为病因学研究提供重要影像学依据。

外文摘要：Objective To investigate CT value changes in the left frontal lobe and its relationship with clinical features of patients with paranoia first- episode schizophrenia（PFES）.Methods The brain CT images of 200 patients diagnosed as PFES clinically were retrospectively analyzed.The CT value in the left frontal lobe of PEFS patients were measured and compared with that of 180 healthy subjects（control group）.The correlation of CT value in the left frontal lobe with clinical parameters of PFES patients were analyzed.Results The CTvalue in the left frontallobe ofPFES patients was（34.12± 1.45）HU,which was lowerthan that of control group（38.36± 1.26）HU significantly（P〈0.01）.The CTvalue in the left frontallobe of male and female PFES patients were（34.13± 1.18）,（33.96± 1.51） HU,there were no statistically significant difference（P 〉0.05）.The PFES patients with the age more or less than 30 years were（33.85± 1.01）,（34.25± 1.26） HU respectively（P 〉0.05）.There was no correlation between the CT value of the left frontal lobe and the age of PFES patients（r=0.08,P〉 0.05）.With different level of education,PANSS grades,disease course,living environment and occupation,there was no statistical significance of the CT value in the left frontallobe of PFES patients（all P 〉0.05）.Conclusion The CT value in the left frontallobe of PFES patientsisdecreased,which supports the brain la terality hypothesis ofPFES.Itprovides important imaging basis for etiological study.