文献类型：期刊文献

英文题名：Phase-Domain Photoacoustic Mechanical Imaging for Quantitative Elastography and Viscography

作者：Yang, Fen[1,2,3];Chen, Zhongjiang[4];Wang, Pingping[5];Shi, Yujiao[6,7,8]

机构：[1]South China Normal Univ, Coll Biophoton, MOE Key Lab Laser Life Sci, Guangzhou, Peoples R China;[2]South China Normal Univ, Inst Laser Life Sci, Coll Biophoton, Guangzhou, Peoples R China;[3]Southern Univ Sci & Technol, Dept Biomed Engn, Guangzhou, Peoples R China;[4]Fujian Med Univ, Sch Med Technol & Engn, Fuzhou, Peoples R China;[5]Shaoxing Univ, Sch Med, Dept Clin Med, Shaoxing, Peoples R China;[6]South China Normal Univ, MOE Key Lab Laser Life Sci, Guangzhou 510631, Peoples R China;[7]South China Normal Univ, Inst Laser Life Sci, Guangzhou 510631, Peoples R China;[8]South China Normal Univ, Coll Biophoton, Guangdong Prov Key Lab Laser Life Sci, Guangzhou, Peoples R China

年份：2024

卷号：71

期号：8

起止页码：2330

外文期刊名：IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING

收录：SCI-EXPANDED(收录号：WOS:001273933600017)、、EI(收录号：20240915653236)、Scopus(收录号：2-s2.0-85186069037)、WOS

基金：This work was supported in part by the National Natural Science Foundation of China under Grant 61627827, Grant 61705068, and Grant 62275116, in part by the Science and Technology Program of Guangzhou under Grant 2019050001, in part by the Natural Science Foundation of Fujian Province under Grant 2021J01813, and in part by China Postdoctoral Science Foundation under Grant 2022M721483.

语种：英文

外文关键词：Photoacoustic; elasticity imaging; viscosity imaging; viscoelastic properties; Photoacoustic; elasticity imaging; viscosity imaging; viscoelastic properties

外文摘要：The role and importance of mechanical properties of cells and tissues in pathophysiological processes have widely been acknowledged. However, current elastography techniques most based on transverse elastic waves, diminish the translation of wave speed into elastic modulus due to its limited wave propagation direction. Here, we propose phase-domain photoacoustic mechanical imaging (PD-PAMI), leveraging the initial time and phase response characteristics of an omnidirectional photoacoustic elastic wave to quantitatively extract elastic and viscous moduli. Theoretical simulations and experiment on tissue-mimicking phantoms with different levels of viscoelastic properties were conducted to validate the approach with a precision in elasticity and viscosity estimation of 4.6% and 6.6%, respectively. The trans-scale viscoelasticity mappings over three length scales-covering cell, tissue section, and in vivo organ, were provided to demonstrate the scalability of the technique with different implementations of PD-PAMI. Experiments on animal models of breast tumour and atherosclerosis reveal that PD-PAMI technique enables effective monitoring of the viscoelastic parameters for examinations of the diseases involved with the variations in collagen or lipid composition and in inflammation level. PD-PAMI technique opens new perspectives of conventional PA imaging and provides new technical way for biomechanical imaging, prefiguring potential clinical applications in mechanopathology-involved disease diagnosis.