文献类型：期刊文献

英文题名：Neuropsychiatric sequelae after liver transplantation and their possible mechanism via the microbiota-gut-liver-brain axis

作者：Jing, Wenhao[1,2,3];Bi, Chenchen[3];Fang, Zhou[4];Qian, Chao[1];Chen, Jiaqi[2,5];Yu, Jingru[3];Tian, Guoqiang[1];Ye, Mengfei[1];Liu, Zheng[2]

机构：[1]Shaoxing Univ, Shaoxing peoples Hosp 7, Mental Hlth Ctr, Dept Psychiat,Sch Med, Shaoxing 312000, Zhejiang, Peoples R China;[2]Shaoxing Univ, Sch Med, Dept Pharmacol, Shaoxing 312000, Zhejiang, Peoples R China;[3]Shaoxing Univ, Sch Med, Dept Clin Med, Shaoxing 312000, Zhejiang, Peoples R China;[4]Shaoxing Second Hosp, Dept Gen Practice, Lizhu Branch, Shaoxing 312000, Zhejiang, Peoples R China;[5]Guangdong Prov Peoples Hosp, Guangdong Acad Med Sci, Dept Emergency Med, Guangzhou 510080, Guangdong, Peoples R China

年份：2023

卷号：163

外文期刊名：BIOMEDICINE & PHARMACOTHERAPY

收录：SCI-EXPANDED(收录号：WOS:001000722500001)、、Scopus(收录号：2-s2.0-85156209858)、WOS

语种：英文

外文关键词：Liver transplantation; Depression; Post-traumatic stress disorder; Microbiota-gut-liver-brain axis; Sleep disorder; anxiety

外文摘要：Patients after liver transplantation are often impacted by mental and even neuropsychiatric disorders, including depression, sleep disorders, anxiety, and post-traumatic stress disorder. Neuropsychiatric sequelae have an adverse impact on rehabilitation and can even incapacitate people, reducing their quality of life. Despite screening tools and effective treatments, neuropsychiatric sequelae after liver transplantation (NSALT) have not been fully diagnosed and treated. Current research suggests that NSALT may be partly related to intestinal microbial variation, but the detailed mechanism remains unclear. In this review, we describe the clinical and diagnostic features, prevalence, prediction, clinical course and outcome, management, and treatment of NSALT; we also summarize their mechanisms through the microbiota-gut-liver-brain axis. Finally, we propose to improve NSALT on the basis of adjusting the gastrointestinal flora, immune inflammation or vagus nerve (VN), providing a novel strategy for clinical prevention and treatment.