文献类型：期刊文献

英文题名：Expression of 34 beta E12 may be an independent predictor of survival in breast cancer

作者：Wang, Chuchu[1];Wei, Jiangguo[3];Huang, Liming[1,2];Xu, Chaoyang[1,2]

机构：[1]Shaoxing Univ, Affiliated Hosp 1, Med Coll, Dept Breast & Thyroid Surg, Shaoxing, Zhejiang, Peoples R China;[2]Shaoxing Univ, Affiliated Hosp 1, Dept Med Res Ctr, Shaoxing, Zhejiang, Peoples R China;[3]Shaoxing Univ, Affiliated Hosp 1, Dept Pathol, Shaoxing, Zhejiang, Peoples R China

年份：2021

卷号：49

期号：10

外文期刊名：JOURNAL OF INTERNATIONAL MEDICAL RESEARCH

收录：SCI-EXPANDED(收录号：WOS:000710512900001)、、WOS

基金：The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This study was supported by grants from the National Natural Science Foundation of China (Grant no: 81341135), Zhejiang non-profit technology applied research projects of China (Grant no: LGF20H160017).

语种：英文

外文关键词：Breast cancer; HMW cytokeratins; 34 beta E12; Prognosis; Oestrogen receptor; progesterone receptor; Human epidermal growth factor receptor-2; Ki67

外文摘要：Objectives: To investigate the relationship between high-molecular-weight cytokeratin (34 beta E12) and clinicopathological parameters (including HER-2, Ki67 and steroid receptors) in breast cancer to determine its usefulness as a prognostic marker. Methods: In this retrospective study, the expression level 34 beta E12 was assessed in surgically resected breast cancer specimens by immunohistochemical staining. Data were correlated with the patients' clinicopathological parameters. Results: Of the 348 breast cancer tissue samples, 232 (67%) showed positive expression of 34 beta E12. There were statistically significant differences between the positive and negative 34 beta E12 expression groups in tumour size, lymph node involvement, oestrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor-2 (HER2) status. There were no differences between groups in age, tumour grade, or Ki67 status. In addition, patients who were positive for 34 beta E12 had significantly extended overall survival. In multivariate analysis, the expression level of 34 beta E12 was found to be a significant independent prognostic factor. Conclusion: These results suggest that positive 34 beta E12 expression is associated with a favourable outcome in breast cancer and so may be a useful prognostic factor. Further studies are required to confirm these results.