文献类型：期刊文献

中文题名：特发性血小板减少性紫癜患儿血清和骨髓激活素A的变化及意义

英文题名：Levels of activin a in serum and bone marrow in children with idiopathic thrombocytopenic purpura

作者：张子彦[1];张敏[1];王国平[2]

机构：[1]绍兴文理学院附属医院内科;[2]山西省长治市人民医院儿科

年份：2010

期号：1

起止页码：18

中文期刊名：中国小儿血液与肿瘤杂志

外文期刊名：Journal of China Pediatric Blood and Cancer

收录：CSTPCD

语种：中文

中文关键词：激活素A;紫癜,血小板减少性;酶联免疫吸附法;儿童

外文关键词：Activin A; purpura; thrombocytopenic; enzyme linked immunosorbent assay; children

中文摘要：目的探讨血清和骨髓激活素A在急性特发性血小板减少性紫癜(ITP)患儿的变化意义。方法收集91例ITP患儿治疗前后及20例相对正常儿童血清和骨髓上清,采用酶联免疫吸附法(ELISA)测定血清和骨髓激活素A浓度。结果急性ITP患儿治疗前血清和骨髓激活素A浓度均高于正常对照组(P<0.05)和治疗后组(P<0.05),治疗后组与正常对照组相比均无显著性差异(P>0.05)。慢性ITP患儿无效组治疗前后血清和骨髓激活素A浓度相比,差异均无统计学意义(P>0.05)。有效组治疗后血清和骨髓激活素A与治疗前相比,差异均有统计学意义(P<0.01)。结论激活素A的变化可能与ITP患儿的病情变化有关。

外文摘要：Objective To study the changes and effects of activin A in serum and bone marrow of children with idiopathic thrombocytopenic purpura（ITP）.Methods Levels of activin A from serum and bone marrow,which were detected using enzyme linked immunosorbent assay（ELISA）,were.respectively collected from 91 children with ITP and 20 comparably normal children.Results The activin A levels in serum and bone marrow of the acute ITP（AITP） group detected before therapy were higher than that of the normal group（P0.05）,and also higher than the actvin A levels of the AITP group detected after therapy（P0.05）.The activinA levels of the AITP group collected after therapy and that of the normal group had no significant difference（P0.05）.There is no significant difference between the activin A levels of refractory patients with chronic ITP（CITP） detected before therapy and after therapy（P0.05）,but the activin A levels of the CITP group with good treatment effect detected before therapy were higher than that of the normal group（P0.01） and also higher than the actvin A levels of the CITP group detected after therapy（P0.05）.Conclusion The changes of activin A levels may take part in the pathogenesis of ITP.