文献类型：期刊文献

英文题名：Relationship between gray matter structure and age in children and adolescents with high-functioning autism spectrum disorder

作者：Sun, Fenfen[1,2];Chen, Yue[1,2];Huang, Yingwen[1,2];Yan, Jing[1,2];Chen, Yihong[3]

机构：[1]Shaoxing Univ, Ctr Brain Mind & Educ, Shaoxing, Peoples R China;[2]Shaoxing Univ, Dept Psychol, Shaoxing, Peoples R China;[3]First Peoples Hosp Xiaoshan, Dept Otorhinolaryngol, Hangzhou, Peoples R China

年份：2023

卷号：16

外文期刊名：FRONTIERS IN HUMAN NEUROSCIENCE

收录：SCI-EXPANDED(收录号：WOS:000914014700001)、、Scopus(收录号：2-s2.0-85146512144)、WOS

基金：Funding This work was supported by a grant sponsored by the Research Program of Zhejiang Federation of Humanities and Social Sciences Circles (2023N089).

语种：英文

外文关键词：autism spectrum disorder (ASD); gray matter structure; children and adolescents; age; regression analysis

外文摘要：ObjectiveThe present study used magnetic resonance imaging to investigate the difference in the relationship between gray matter structure and age in children and adolescents with autism spectrum disorder (ASD) and typically developing (TD) subjects. MethodsAfter screening T1 structural images from the Autism Brain Imaging Data Exchange (ABIDE) database, 111 children and adolescents (7-18 years old) with high-functioning ASD and 151 TD subjects matched for age, sex and full IQ were included in the current study. By using the voxel-based morphological analysis method, gray matter volume/density (GMV/GMD) maps were obtained for each participant. Then, a multiple regression analysis was performed for ASD and TD groups, respectively to estimate the relationship between GMV/GMD and age with gender, education, site, and IQ scores as covariates. Furthermore, a z-test was used to compare such relationship difference between the groups. ResultsResults showed that compared with TD, the GMD of ASD showed stronger positive correlations with age in the prefrontal cortex, and a stronger negative correlation in the left inferior parietal lobule, and a weaker positive correlation in the right inferior parietal lobule. The GMV of ASD displayed stronger positive correlations with age in the prefrontal cortex and cerebellum. ConclusionThese findings may provide evidence to support that the brain structure abnormalities underlying ASD during childhood and adolescence may differ from each other.