文献类型：期刊文献

英文题名：The mechanism of cuproptosis in Parkinson's disease

作者：Huang, Min[1];Zhang, Yong[1];Liu, Xuehong[1,2]

机构：[1]Shaoxing Univ, Sch Med, Dept Histol & Embryol, Shaoxing, Zhejiang, Peoples R China;[2]Shaoxing Univ, Sch Med, Dept Histol & Embryol, Shaoxing 312000, Zhejiang, Peoples R China

年份：2024

卷号：95

外文期刊名：AGEING RESEARCH REVIEWS

收录：SCI-EXPANDED(收录号：WOS:001186045100001)、、Scopus(收录号：2-s2.0-85183945920)、WOS

语种：英文

外文关键词：Cuproptosis; Copper; Glutathione; Dopamine; alpha-synuclein; Parkinson's disease

外文摘要：Parkinson's disease (PD) is a neurodegenerative disease with an increased morbidity. The pathogenesis PD has not been fully elucidated, and whatever mechanism is involved, it ultimately leads to dopamine (DA) neuronal apoptosis. Cuproptosis is a novel form of cell death. Its morphology, biochemical properties, and mechanism of action differ from known forms of cell death, such as apoptosis, autophagy, necrosis and pyroptosis. Copper binds to the lipoylated components of the tricarboxylic acid cycle, causing proteotoxic stress that ultimately leads to cellular cuproptosis. PD has biochemical features such as mitochondrial dysfunction and decreased levels of copper and glutathione in brain regions. This is closely related to the cuproptosis mechanism. However, the specific link between the pathogenesis of PD and cuproptosis is unclear. Herein, we summarizes cuproptosis as the cause of DA neuronal death in PD, and the relationship between cuproptosis and the PD pathogenesis. This article provides a research basis for targeted cuproptosis for PD.