文献类型：期刊文献

英文题名：The Function of the Metals in Regulating Epigenetics During Parkinson's Disease

作者：Wei, Xiangzhen[1];Cai, Menghua[2,3];Jin, Lifang[4]

机构：[1]Xian Jiaotong Liverpool Univ, Dept Biol Sci, Suzhou, Peoples R China;[2]Chinese Acad Med Sci, Dept Immunol, Inst Basic Med Sci, Beijing, Peoples R China;[3]Peking Union Med Coll, Sch Basic Med, Beijing, Peoples R China;[4]Shaoxing Univ, Dept Biol Sci, Shaoxing, Peoples R China

年份：2021

卷号：11

外文期刊名：FRONTIERS IN GENETICS

收录：SCI-EXPANDED(收录号：WOS:000618212300001)、、Scopus(收录号：2-s2.0-85100887399)、WOS

语种：英文

外文关键词：Parkinson’ s disease; epigenetic; metal; DNA methylation; synucleinopathy

外文摘要：Parkinson's means Parkinson's disease, a chronic degenerative disease of central nervous system. The main area which is affected by this disease is motor system. Since it firstly founded by James Parkinson in his 1817 publication, nowadays, people still have lots of questions about this disease. This review mainly summarizes the epigenetics of Parkinson's. DNA methylation is one of the epigenetic mechanisms of Parkinson's. During the development of disease, global hypomethylation, and hypermethylation happen in different areas of patients. Another epigenetic mechanism is histone modification. People believe that some metals can induce Parkinson's disease by modulating epigenetic mechanisms. This review summarizes the relationships between different metals and Parkinson's disease. However, the specific roles of most metals in epigenetics are still unknown, which need further research.