文献类型：期刊文献

英文题名：High-frequency repetitive transcranial magnetic stimulation of the left dorsolateral prefrontal cortex may reduce impulsivity in patients with methamphetamine use disorders: A pilot study

作者：Liu, Qingming[1,2,3];Xu, Xingjun[4];Cui, Huimin[1,2];Zhang, Lei[5];Zhao, Zhiyong[6];Dong, Da[1,2];Shen, Ying[4]

机构：[1]Shaoxing Univ, Ctr Brain Mind & Educ, Shaoxing, Peoples R China;[2]Shaoxing Univ, Dept Psychol, Shaoxing, Peoples R China;[3]Nanjing Normal Univ, Sch Psychol, Nanjing, Peoples R China;[4]Nanjing Med Univ, Affiliated Hosp 1, Rehabil Med Ctr, Nanjing, Peoples R China;[5]Nanjing Xiaozhuang Univ, Sch Early Childhood Educ, Nanjing, Peoples R China;[6]Zhejiang Univ, Coll Biomed Engn & Instrument Sci, Dept Biomed Engn, Key Lab Biomed Engn,Minist Educ, Hangzhou, Peoples R China

年份：2022

卷号：16

外文期刊名：FRONTIERS IN HUMAN NEUROSCIENCE

收录：SCI-EXPANDED(收录号：WOS:000843114500001)、、Scopus(收录号：2-s2.0-85136934929)、WOS

基金：This study was funded by the National Science Foundation of China (Grant No. 81702230), the Nanjing Municipal Science and Technology Bureau (Grant No. 2019060002), the National Key R&D Program of China (Grant Nos. 2022YFC2009700 and 2022YFC2009701), and the National Social Science Fund of China (Grant No. 20CZX015).

语种：英文

外文关键词：rTMS; left DLPFC; MAUD; craving; impulsivity

外文摘要：BackgroundIndividuals who use methamphetamine (MA) for a long period of time may experience decreased inhibition and increased impulsivity. In order to reduce impulsivity or improve inhibitory control ability, high-frequency repetitive transcranial magnetic stimulation (HF-rTMS) has attracted much attention of researchers. Recent studies on addiction have shown that rTMS can stimulate different brain regions to produce different therapeutic effects. Recent work also suggests that HF-rTMS over right dorsolateral prefrontal cortex (DLPFC) does not affect the impulsivity of patients with alcohol use disorder; while HF-rTMS over left DLPFC could improve the impulsivity of patients with alcohol use disorder and cigarette smokers. However, it should be noted that empirical studies applying HF-rTMS over left DLPFC of patients with MA use disorders (MAUD) (to evaluate its effect on impulsivity) are still lacking. MethodsTwenty-nine patients with MAUD underwent five sessions of HF-rTMS on the left DLPFC per week for 4 consecutive weeks. The cue-induced craving and stop-signal and NoGo task were assessed pre-rTMS and post-rTMS (at the end of the 4-week rTMS treatment). In addition, 29 healthy controls were recruited. There was no rTMS intervention for the controls, the performance of the stop-signal and NoGo task was evaluated on them. ResultsIn total, HF-rTMS of the left DLPFC significantly decreased MA-dependent patients' cue-induced craving and stop-signal reaction time (SSRT). For SSRT, the pre-test of experimental group was significantly higher than the score of control group. In the experimental group, the pre-test score was significantly higher than the post-test score. For Go and stop-signal delay (SSD), the pre-test scores of the experimental group was significantly lower than the scores of the control group. No significant difference was found between the pre-test and the post-test scores of the experimental group. ConclusionAdd-on HF-rTMS of left DLPFC may be an effective intervention for reducing impulsivity and cue-induced craving of patients with MAUD. Future research with a control group of MAUD that does not undergo the treatment is needed to confirm the effectiveness.