文献类型：期刊文献

英文题名：Combinational Treatment of Bioscaffolds and Extracellular Vesicles in Spinal Cord Injury

作者：Wang, Xizhi[1];Botchway, Benson O. A.[2];Zhang, Yong[1];Yuan, Jiaying[1];Liu, Xuehong[1]

机构：[1]Shaoxing Univ, Med Coll, Dept Histol & Embryol, Shaoxing, Zhejiang, Peoples R China;[2]Zhejiang Univ, Inst Neurosci, Sch Med, Hangzhou, Zhejiang, Peoples R China

年份：2019

卷号：12

外文期刊名：FRONTIERS IN MOLECULAR NEUROSCIENCE

收录：SCI-EXPANDED(收录号：WOS:000464491900001)、、Scopus(收录号：2-s2.0-85066949585)、WOS

基金：This work was supported by the Natural Science Foundation of Zhejiang Province (No. LY19H170001) and Public Technology Applied Research Projects Foundation of Shaoxing City (No. 2017B70066).

语种：英文

外文关键词：spinal cord injury; stem cell therapy; neuronal damage; functional and axonal regeneration; bioscaffolds; extracellular vesicles

外文摘要：Spinal cord injury (SCI) can result in an irreversible disability due to loss of sensorimotor function below the lesion. Presently, clinical treatments for SCI mainly include surgery, drugs and postoperative rehabilitation. The prospective roles of bioscaffolds and exosomes in several neurological diseases have been reported. Bioscaffolds can reconnect lesion gaps as well as transport cells and bioactive factors, which in turn can improve axonal and functional regeneration. Herein, we explicate the respective roles of bioscaffolds and exosomes in SCI, and elucidate on the usage of combinational therapy involving bioscaffolds and extracellular vesicles (EVs) in improving SCI.