文献类型：期刊文献

英文题名：Activity-Dependent Neurorehabilitation Beyond Physical Trainings: "Mental Exercise" Through Mirror Neuron Activation

作者：Yuan, Ti-Fei[1];Chen, Wei[2];Shan, Chunlei[3,4];Rocha, Nuno[5];Arias-Carrion, Oscar[6];Paes, Flavia[7];de Sa, Alberto Souza[7];Machado, Sergio[7,8]

机构：[1]Nanjing Normal Univ, Sch Psychol, Nanjing, Jiangsu, Peoples R China;[2]Shaoxing Univ, Dept Psychol, Shaoxing, Peoples R China;[3]Shanghai Univ Tradit Chinese Med, Shanghai, Peoples R China;[4]Nanjing Med Univ, Affiliated Hosp 1, Dept Rehabil Med, Nanjing, Jiangsu, Peoples R China;[5]Polytech Inst Porto, Sch Allied Hlth Sci, Oporto, Portugal;[6]Hosp Gen Dr Manuel Gea Gonzalez IFC UNAM, Unidad Trastornos Movimiento & Sueno TMS, Mexico City, DF, Mexico;[7]Univ Fed Rio de Janeiro, Inst Psychiat, Lab Pan & Respirat, Rio De Janeiro, RJ, Brazil;[8]Univ Salgado de Oliveira, Phys Act Sci Postgrad Program, Phys Act Neurosci, Niteroi, RJ, Brazil

年份：2015

卷号：14

期号：10

起止页码：1267

外文期刊名：CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS

收录：SCI-EXPANDED(收录号：WOS:000365808000004)、、Scopus(收录号：2-s2.0-84959453651)、WOS

基金：The study is supported by "Hundred Talents program", "Qing Lan Project" of Nanjing Normal University and Jiangsu Provincial Natural Science Foundation (No. BK20140917) (TY). China Postdoctoral Science Foundation (No. 2014T70578, No. 2013M540497)(CW). The study was also supported by National Natural Science Foundation of China (No. 81171853, No. 81472163), Jiangsu Provincial Natural Science Foundation (No. BK2011850), Six Talents Peak Project of Jiangsu Province (No. N2011-WS-100), Health Promotion Project of Health Department of Jiangsu Province (No. XK20200903), Jiangsu Provincial Special Program of Medical Science (BL2012029), and Jiangsu Province "XINGWEI Program" key discipline grant (CS).

语种：英文

外文关键词：Mirror neuron system; brain stimulation; neurorehabilitation; stroke

外文摘要：The activity dependent brain repair mechanism has been widely adopted in many types of neurorehabilitation. The activity leads to target specific and non-specific beneficial effects in different brain regions, such as the releasing of neurotrophic factors, modulation of the cytokines and generation of new neurons in adult hood. However physical exercise program clinically are limited to some of the patients with preserved motor functions; while many patients suffered from paralysis cannot make such efforts. Here the authors proposed the employment of mirror neurons system in promoting brain rehabilitation by "observation based stimulation". Mirror neuron system has been considered as an important basis for action understanding and learning by mimicking others. During the action observation, mirror neuron system mediated the direct activation of the same group of motor neurons that are responsible for the observed action. The effect is clear, direct, specific and evolutionarily conserved. Moreover, recent evidences hinted for the beneficial effects on stroke patients after mirror neuron system activation therapy. Finally some music-relevant therapies were proposed to be related with mirror neuron system.