文献类型：期刊文献

中文题名：实验性糖尿病大鼠巨噬细胞内酶活性及吞噬功能的研究

英文题名：Study of enzyme activity and phagocytic capacity of macrophage obtained from experimental diabetic rats

作者：陈国荣[1];金丽琴[2];邵黎明[1];吕建新[2];胡芸[1];陈三妹[3]

机构：[1]温州医学院病理学教研室;[2]温州医学院检验系;[3]绍兴文理学院护理系

年份：2000

卷号：16

期号：5

起止页码：352

中文期刊名：免疫学杂志

外文期刊名：IMMUNOLOGICAL JOURNAL

收录：CSTPCD、、北大核心1996、CSCD2011_2012、北大核心、CSCD

语种：中文

中文关键词：糖尿病;巨噬细胞;酶活性;吞噬功能;大鼠;并发症

外文关键词：diabetes mellitus;macrophage;enzyme activity;phagocytosis

中文摘要：目的研究实验性糖尿病大鼠巨噬细胞内酶活性及其吞噬功能。方法用四氧嘧啶腹腔注射复制 SD大鼠糖尿病动物模型 ,测定大鼠肺泡及腹腔巨噬细胞内酸性磷酸酶 ,精氨酸酶 ,乳酸脱氢酶及异柠檬酸脱氢酶的活性并测定腹腔及肺泡巨噬细胞对中性红的吞噬能力。结果糖尿病大鼠肺泡及腹腔巨噬细胞内 4种酶活性均高于对照组 ,其对中性红的吞噬能力也大于对照组。结论糖尿病时巨噬细胞处于激活状态 ,此激活的巨噬细胞可能参与糖尿病并发症之发生。

外文摘要：ObjectiveTo investigate the enzyme activity and phagocytic capacity of macrophages obtained from the diabetic rats.MethodsDiabetic model of Spraguc Dauley rats was made by intraperitoneal injection of alloxan.The activity of acid phosphatase,arginase,lactate dehydrogenase and isocitrate dehydrogenase of alveolar and peritoneal macrophage obtained from rats was studied.The phagocytic capacity of macrophage to neutral red was observed.ResultsThe activity of the four kinds of enzymes of alveolar and peritoneal macrophage from the diabetic rats was higher than that of the control.The phagocytic capacity of macrophage was stronger than that of the control.ConclusionThe macrophage of the diabetic rats was in a state of activation and this activated macrophage may mediate the development of complications of diabetes mellitus.