文献类型：期刊文献

中文题名：微管相关蛋白2和巢蛋白在人胚胎胃组织中的表达

英文题名：Microtubule-associated protein 2 and nestin expressions in human embryonic and fetal gastric tissues

作者：刘学红[1];张泳[1]

机构：[1]绍兴文理学院医学院

年份：2012

卷号：32

期号：9

起止页码：1328

中文期刊名：南方医科大学学报

外文期刊名：Journal of Southern Medical University

收录：MEDLINE(收录号：22985576)、CSTPCD、、北大核心2011、Scopus(收录号：2-s2.0-84880622891)、CSCD2011_2012、北大核心、CSCD、PubMed

基金：浙江省教育厅科研计划项目(Y201018535);绍兴文理学院重点项目(2010LG1011)

语种：中文

中文关键词：胃;微管相关蛋白2;巢蛋白;人胚胎

外文关键词：stomach; microtubule-associated protein 2; nestin; human embryos; human fetuses

中文摘要：目的探讨微管相关蛋白2(MAP-2)和巢蛋白(Nestin)与人胚胎胃组织的发育关系。方法应用免疫组织化学PV法检测第2、3、4三个月龄段,人胚胎胃壁、贲门和幽门组织内MAP-2和Nestin的表达规律。结果第2、3、4三个月龄段,MAP-2和Nestin阳性表达主要集中于人胚胎胃壁、贲门和幽门组织黏膜下神经丛和肌间神经丛,随胎龄的增大,MAP-2和Nestin蛋白在肌间神经丛内阳性表达细胞数量和强度均呈增高趋势。而MAP-2和Nestin蛋白在胃壁、贲门和幽门组织的黏膜上皮和腺体处均呈阴性表达。结论 MAP-2和Nestin参与调节人胚胎胃组织的生长发育过程。

外文摘要：Objective To investigate the role of microtubule-associated protein 2 （MAP-2） and nestin in gastric development in human embryos and fetuses. Methods Immunohistochemistry was used to detect the expressions of MAP-2 and nestin proteins in the gastric cardia, pyloric and gastric tissues of human embryos and fetuses during the second, third and fourth month of development. Results In the second to fourth months of gestation, MAP-2 and nestin expressions were detected in the neural cells and neural fibers of the intermuscular nerve plexus and submucosal plexus in the gastric cardia, pyloric and gastric tissues. As the gestational age increased, the number of MAP-2- and nestin-positive ceils and the expression intensity all increased in the myenteric plexus, but MAP-2 and nestin expressions were negative in the glandular and mucosal tissues of human embryonic and fetal gastric cardia, pylorus or gastric wails. Conclusion MAP-2 and nestin participate in the regulation of the development of gastric tissues in human embryos.