文献类型：期刊文献

中文题名：血清MMP-9、IGF-1、CRP和IMT与2型糖尿病无症状心肌缺血的关系

英文题名：Relationship between intima-media thickness,matrix metalloproteinase-9,insulin growth-like factor-1,and C-reactive and type 2 diabetes with silent myocardial ischemia

作者：张敏[1];张剑[2]

机构：[1]绍兴文理学院附属医院内分泌科,312000;[2]绍兴文理学院医学院药理教研室,312000

年份：2008

卷号：24

期号：12

起止页码：2079

中文期刊名：实用医学杂志

外文期刊名：The Journal of Practical Medicine

收录：CSTPCD

基金：浙江省教育厅资助课题(编号:20070497);绍兴市科技局资助课题(编号:2007A33001)

语种：中文

中文关键词：糖尿病,2型;心肌缺血;明胶酶B;胰岛素样生长因子I;内膜中层厚度

外文关键词：Diabetes mellitus, type 2 Myocardial ischemia Gelatinase B Insulin-like growth factor Ⅰ Intima-media thickness

中文摘要：目的:探讨颈动脉内膜中层厚度(IMT)和血清基质金属蛋白酶-9(MMP-9)、胰岛素样生长因子-1(IGF-1)、C反应蛋白(CRP)与2型糖尿病(T2DM)合并无症状心肌缺血(SMI)的关系。方法:分别用彩色多普勒超声法和酶联免疫吸附法(ELISA)测定45例T2DM患者(对照组)和71例T2DM合并SMI患者(SMI组)的IMT和血清MMP-9、IGF-1、CRP水平。结果:SMI组IMT和血清MMP-9、CRP水平较对照组明显升高(P<0.01或P<0.05),IGF-1与对照组相比没有明显变化(P>0.05)。MMP-9、CRP与IMT呈显著正相关。结论:颈动脉IMT、MMP-9和CRP指标的测定有助于临床上认识糖尿病大血管病变发生的危险性,从而早期积极采取有效的干预措施。

外文摘要：Objective To study the relationship between intima-media thickness （IMT） of common carotid artery, matrix metalloproteinase-9 （MMP-9）, insulin growth-like factor-1 （IGF-1）, C-reactive protein （CRP） and silent myocardial ischemia （SMI） in type 2 diabetes. Methods IMT was measured by B-mode uhrasonography and serum levels of MMP-9, IGF-1, and CRP were determined by enzyme linked immunosorbent assay （ELISA） in 45 patients with type 2 diabetes and 71 type 2 diabetics with SMI. Results IMT and levels of MMP-9 and CRP were significantly higher in type 2 diabetics with SMI than in those without SMI （P 〈 0.01 or P 〈 0.05）. IGF-1 level did not differ significantly between the two groups （P 〉 0.05）. MMP-9 and CRP were markedly related with IMT. Conclusion Detection of IMT, MMP-9, and CRP can be helpful in clinically identifying the risk of the incidence of vascular events in type 2 diabetes.