文献类型：期刊文献

英文题名：A Versatile PDA(DOX) Nanoplatform for Chemo-Photothermal Synergistic Therapy against Breast Cancer and Attenuated Doxorubicin-Induced Cardiotoxicity

作者：Geng, Siqi[1,2];Feng, Qiang[2];Wang, Chujie[2];Li, Ying[2];Qin, Jiaying[2];Hou, Mingsheng[3];Zhou, Jiedong[2];Pan, Xiaoyu[2];Xu, Fei[4];Fang, Baoru[1,2];Wang, Ke[1,2];Yu, Zhangsen[1,2]

机构：[1]Shaoxing Univ, Sch Life & Environm Sci, Shaoxing 312000, Zhejiang, Peoples R China;[2]Shaoxing Univ, Sch Med, Med Sci Res Ctr, Lab Nanomed, Shaoxing 312000, Zhejiang, Peoples R China;[3]Shaoxing Hosp Tradit Chinese Med, Dept Pathol, Shaoxing 312000, Zhejiang, Peoples R China;[4]Shaoxing Univ, Dept Ultrasound, Affiliated Hosp, Shaoxing 312000, Zhejiang, Peoples R China

年份：2023

卷号：21

期号：1

外文期刊名：JOURNAL OF NANOBIOTECHNOLOGY

收录：SCI-EXPANDED(收录号：WOS:001071488600003)、、EI(收录号：20233914781099)、Scopus(收录号：2-s2.0-85171869151)、WOS

基金：This work was financially supported by the project of Zhejiang Provincial Natural Science Foundation (LGF21H180005, LTGY23H020002), the Science and Technology Plan in Shaoxing City (2022A14026), Zhejiang University Laboratory Work Research Project (YB202219). College Students & apos; Science and Technology Innovation Project of Zhejiang Province (2022R432A026). Medical and Health Science and Technology Plan Project of Zhejiang Province (2021KY1159). Medical and Health Science and Technology Plan Project of Shaoxing (2020A13024, 2020A13060).

语种：英文

外文关键词：Polydopamine; Photothermal-chemotherapy synergistic therapy; Doxorubicin-induced cardiotoxicity; Oxidative stress

外文摘要：Photothermal therapy (PTT) is a highly clinical application promising cancer treatment strategy with safe, convenient surgical procedures and excellent therapeutic efficacy on superficial tumors. However, a single PTT is difficult to eliminate tumor cells completely, and tumor recurrence and metastasis are prone to occur in the later stage. Chemo-photothermal synergistic therapy can conquer the shortcomings by further killing residual tumor cells after PTT through systemic chemotherapy. Nevertheless, chemotherapy drugs' extreme toxicity is also a problematic issue to be solved, such as anthracycline-induced cardiotoxicity. Herein, we selected polydopamine nanoparticles (PDA) as the carrier of the chemotherapeutic drug doxorubicin (DOX) to construct a versatile PDA(DOX) nanoplatform for chemo-photothermal synergistic therapy against breast cancer and simultaneously attenuated DOX-induced cardiotoxicity (DIC). The excellent photothermal properties of PDA were used to achieve the thermal ablation of tumors. DOX carried out chemotherapy to kill residual and occult distant tumors. Furthermore, the PDA(DOX) nanoparticles significantly alleviate DIC, which benefits from PDA's excellent antioxidant enzyme activity. The experimental data of the chemotherapy groups showed that the results of the PDA(DOX) group were much better than the DOX group. This study not only effectively inhibits cancer but tactfully attenuates DIC, bringing a new perspective into synergistic therapy against breast cancer.