文献类型：期刊文献

英文题名：Relationships between nutritional status and serum adipokine levels with chemotherapy efficacy in late-stage colorectal cancer patients

作者：Zhang, Wendi[1];Wang, Shanshan[1]

机构：[1]Shaoxing Univ, Dept Infect Dis Hepatol, Affiliated Hosp, 999 Zhongxing South Rd, Shaoxing 312000, Zhejiang, Peoples R China

年份：2025

卷号：40

期号：1

外文期刊名：INTERNATIONAL JOURNAL OF COLORECTAL DISEASE

收录：SCI-EXPANDED(收录号：WOS:001407829300001)、、Scopus(收录号：2-s2.0-85217190198)、WOS

语种：英文

外文关键词：Late-stage colorectal cancer; Nutritional status; Serum adipokine level; Hemoglobin; Adiponectin

外文摘要：ObjectiveColorectal cancer (CRC) is a common cancer, with chemotherapy as its major therapy. Nutritional status (NS) and adipokines implicated in CRC. We explored the impacts of NS indicators (hemoglobin, albumin, and prealbumin) and serum adipokine (visfatin, adiponectin, and resistin) level on chemotherapy efficacy in late-stage CRC patients.MethodsLate-stage CRC patients were divided into the effective and ineffective groups based on chemotherapy efficacy, with clinical data, NS indicator, and serum adipokine levels documented. They were divided into hemoglobin, albumin, prealbumin, visfatin, adiponectin, and resistin high and low expression groups, with their relationships with clinical parameters and chemotherapy efficacy analyzed. Independent risk factors (IRFs) affecting chemotherapy efficacy in late-stage CRC patients were analyzed by logistic multivariate regression.ResultsHemoglobin, albumin, prealbumin, and adiponectin levels were reduced, while NRS 2002 >= 3 proportion, visfatin, and resistin levels were increased in the ineffective group versus the effective group. Areas under receiver operating characteristic curve of hemoglobin, albumin, prealbumin, visfatin, adiponectin, and resistin in diagnosing ineffective chemotherapy were 0.80, 0.88, 0.86, 0.88, 0.83, and 0.83, respectively. NS indicator and serum adipokine levels were markedly associated with chemotherapy efficacy in late-stage CRC patients. Highly expressed albumin and prealbumin were protective factors for effective chemotherapy, and highly expressed visfatin and resistin were risk factors for effective chemotherapy.ConclusionNS indicators and serum adipokine level are correlated with the chemotherapy efficacy in late-stage CRC patients, and both have diagnostic value for chemotherapy efficacy. Albumin, prealbumin, visfatin, and resistin are independent influencing factors affecting chemotherapy efficacy in late-stage CRC patients.