文献类型：期刊文献

英文题名：Carbon Sulfonic Acid-Catalyzed Domino Strategy Enabling Access to the 2-Pyridone Frame Work

作者：Wang, Hongyu[1];Jiang, Lifeng[1];Wang, Jiahong[1];Li, Chunmei[1];Xiao, Huiquan[1];Zhang, Furen[1]

机构：[1]Shaoxing Univ, Sch Chem & Chem Engn, Zhejiang Key Lab Alternat Technol Fine Chem Proc, Shaoxing, Zhejiang, Peoples R China

年份：2025

外文期刊名：ASIAN JOURNAL OF ORGANIC CHEMISTRY

收录：SCI-EXPANDED(收录号：WOS:001492634700001)、、WOS

基金：We are grateful for financial support from the National Natural Science Foundation of China (No. 12275180).

语种：英文

外文关键词：2-Pyridone; Carbon sulfonic acid; Cascade reaction; Synthesis; Water

外文摘要：A general and efficient strategy has been developed for the synthesis of various chain 2-pyridone derivatives in moderate-to-good yields via a carbon sulfonic acid-catalyzed one-pot reaction of 2,2-dihydroxy-1-arylethan-1-one, 2-pyridone, and amine. This protocol features recyclable carbon sulfonic acid, broad substrate flexibility, highly functional group compatibility, and green and mild reaction conditions. More importantly, it enables the rapid acquisition of structurally diverse chain 2-pyridone derivatives by varying the functional groups of the substrates. A plausible mechanism for the domino strategy is proposed based on controlled experiments. This strategy not only provides various chain 2-pyridone derivatives, but also expands the application of carbon sulfonic acids in organic synthesis.