文献类型：期刊文献

中文题名：马蹄香治疗婴幼儿轮状病毒肠炎作用机制的初步探讨

英文题名：Action Mechanism of Valeriana Jatamansii Jones in Treating Rotavirus Enteritis in Infants

作者：张佩红[1];陈啸洪[1];王燕[2];李华浚[1];章杭湖[1]

机构：[1]浙江省绍兴市人民医院(绍兴文理学院第一附属医院);[2]绍兴富盛人民医院

年份：2010

期号：6

起止页码：610

中文期刊名：中国全科医学

外文期刊名：Chinese General Practice

收录：CSTPCD、、Scopus、北大核心2008、CSCD_E2011_2012、北大核心、CSCD

语种：中文

中文关键词：轮状病毒感染;肠炎;免疫球蛋白类;马蹄香;药理机制

外文关键词：Rotavirus infections; Enteritis; Immunoglobulins; Valeriana jatamansii jones; Pharmacologic action

中文摘要：目的探讨马蹄香治疗婴幼儿轮状病毒肠炎的作用机制,研究其对轮状病毒肠炎患儿免疫功能的影响。方法采用ELISA法检测粪便轮状病毒特异性抗原,采用透射比浊法测定血清IgG、IgA、IgM和补体C3、C4水平,采用流式细胞术分析淋巴细胞亚群。将86例轮状病毒肠炎患儿随机分为马蹄香治疗组42例,常规治疗组44例,观察两组的临床疗效、轮状病毒的排出时间及治疗前后免疫性指标的变化。结果两组患儿治疗前血清IgG、IgA、IgM和补体C3、CD3+、CD4+、CD4+/CD8+比值水平较对照组明显降低,CD1+9、CD8+水平升高,差异有统计学意义(P<0.05)。治疗后两组免疫功能均有明显改善,马蹄香治疗组显效35例,有效5例,无效2例,总有效率95.3%;常规治疗组显效30例,有效5例,无效9例,总有效率79.5%;两组总有效率间差异有统计学意义(χ2=4.7439,P<0.05)。结论马蹄香治疗婴幼儿轮状病毒肠炎的作用机制可能与抑制轮状病毒的复制,改善机体的免疫功能有关。

外文摘要：Objective To explore the action mechanism of Valeriana jatamansii jones （VJJ） in treating rotavlrus enteritis in infantsMethods Totally 86 infants with rotavlrus enteritis were enrolled and randomly divided into VJJ group （n = 42） and conventional therapy group （ control group ; n = 44 ）. The clinical effectiveness, excretion of rotavirus, and changes of the immunologic indicators before and after treatment were observed and recorded. Rotavirus - specific antigen was detected using ELISA. The serum levels of immunoglobulins （ IgG, IgA, and IgM） and complements （ C3 and C4 ） were measured with trans- mission turbidimetry. Lymphocyte subsets were detected with flow cytometry. Results Before the treatment, serum IgG, IgA, lgM, C3, CD3^＋ , CD4^ ＋ , CD4^ ＋/CD8^ ＋ ratio were significantly lower and CD19^＋ , CD8 ^＋ levels were significantly higher in VJJ group than in control group （ all P 〈 0.05 ） , while level of C4 had no significant change. The immune functions were remarkably improved in both groups. The effectiveness rate was 95.3% in VJJ group （ highly effective for 35 infants, effective for 5 infants, and failed in 2 infants） and 79. 5% in control group （highly effective for 30 infants, effective for 5 infants, and failed in 9 infants） （ χ^2 = 4. 7439, P 〈 0. 05 ） . Conclusion VJJ can effectively treat rotavirus enteritis in infants by inhibiting the rotavirus replication and improve immune function.