文献类型：期刊文献

英文题名：Assembly of 5H-dibenzo[a,d]cycloheptenes by a formal [5 + 2] annulation of ortho-aryl alkynyl benzyl alcohols with arenes

作者：Zhang, Zhebing[1]; Cai, Tao[1,2,3]; Zhan, Zhaohui[1]; Xu, Huiting[1]; Yu, Lemao[1]; Luo, Xiang[1]; Li, Chunmei[1]; Gao, Yuzhen[4]; Wei, Xuemei[1]; Chen, Xinzhi[3]; Shen, Runpu[1,2]

机构：[1] College of Chemistry and Chemical Engineering, Shaoxing University, Shaoxing, 312000, China; [2] Zhejiang Engineering Research Center of Fat-Soluble Vitamin, China; [3] College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, 310027, China; [4] Key Laboratory of Coal to Ethylene Glycol and Its Related Technology, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fujian, Fuzhou, 350002, China

年份：2022

卷号：20

期号：36

起止页码：7221

外文期刊名：Organic and Biomolecular Chemistry

收录：EI(收录号：20224112850131)、Scopus(收录号：2-s2.0-85138458413)

语种：英文

外文关键词：Aromatic compounds

外文摘要：A new synthetic methodology for the synthesis of 5H-dibenzo[a,d]cycloheptenes from ortho-aryl alkynyl benzyl alcohols and arenes via a Tf2O-mediated formal [5 + 2] annulation reaction has been achieved. From this transformation, structurally diverse 5H-dibenzo[a,d]cycloheptenes were achieved in moderate to good yields. This transformation probably involves an intermolecular Friedel-Crafts-type alkylation and a subsequent intramolecular 7-endo-dig cyclization in one pot, highlighting the high efficiency, regioselectivity, and step-economy of this protocol. ? 2022 The Royal Society of Chemistry.