文献类型：期刊文献

英文题名：Silver-catalyzed Double Decarboxylative Radical Alkynylation/Annulation of Arylpropiolic Acids with alpha-keto Acids: Access to Ynones and Flavones under Mild Conditions

作者：Meng, Mengting[1];Wang, Guofang[1];Yang, Liangfeng[1];Cheng, Kai[1];Qi, Chenze[1]

机构：[1]Shaoxing Univ, Zhejiang Key Lab Alternat Technol Fine Chem Proc, Shaoxing 312000, Peoples R China

年份：2018

卷号：360

期号：6

起止页码：1218

外文期刊名：ADVANCED SYNTHESIS & CATALYSIS

收录：SCI-EXPANDED(收录号：WOS:000428348500023)、、Scopus(收录号：2-s2.0-85041857961)、WOS、CCR-EXPANDED(收录号：WOS:000428348500023)

基金：This work was Supported by the National Natural Science Foundation of China (No. 21402123 and No. 21172149), the Zhejiang Provincial Natural Science Foundation of China (No. LY18B020006 and No. LQ14B020001) and the Science Technology Project of Shaoxing City (No. 2017B70053).

语种：英文

外文关键词：Ynone; Flavone; Silver-catalyzed; Decarboxylative alkynylation; Radical annulation

外文摘要：Ynones are privileged building blocks in various organic syntheses of heterocyclic derivatives due to their multifunctional nature, and flavones are an important class of natural products with a wide range of biological activities. We describe the catalytic double decarboxylative alkynylation of arylpropiolic acids with -keto acids. With Ag(I)/persulfate as the catalysis system, the valuable ynones bearing various substituents could be easily obtained. The introduction of hydroxyl substituent on ortho-site of -keto acids make this strategy further applicable to the construction of flavone derivatives via heteroannulation in moderate to good yields with a similar silver-catalyzed system. The reactions proceed under relatively mild reaction conditions and tolerate a wide variety of functional groups. Control experiments indicated that both the reactions undergo radical processes.