文献类型：期刊文献

英文题名：Association of vitamin D receptor polymorphisms with the risk of prostate cancer in the Han population of Southern China

作者：Bai, Yongheng[1];Yu, Yaping[3];Yu, Bin[3];Ge, Jianrong[3];Ji, Jingzhang[4];Lu, Hong[2];Wei, Jia[1];Weng, Zhiliang[1];Tao, Zhihua[2];Lu, Jianxin[1]

机构：[1]Wenzhou Med Coll, Sch Lab Med & Life Sci, Zhejiang Prov Key Lab Med Genet, Wenzhou 325035, Peoples R China;[2]Affiliated Hosp 1, Wenzhou Med Coll, Lab Diagnost Ctr, Wenzhou 325000, Peoples R China;[3]Shaoxing Univ, Coll Med, Shaoxing 312000, Peoples R China;[4]Affiliated Hosp 1, Wenzhou Med Coll, Dept Urol, Wenzhou 325000, Peoples R China

年份：2009

卷号：10

外文期刊名：BMC MEDICAL GENETICS

收录：SCI-EXPANDED(收录号：WOS:000273006500001)、、Scopus(收录号：2-s2.0-73249116648)、WOS

基金：We thank Dr. Luhu Shan (Zhejiang Cancer Hospital) and Dr. Guiqin Sun (Shaoxing People's Hospital) for their contributions to the subject assistance. This study was sponsored by Zhejiang Provincial Program for the Cultivation of High-level Innovative Health talents and Zhejiang Provincial Top Key Discipline of Laboratory Medicine, and supported by the Shaoxing Scientific Planning Key Project (Grant 2006A23014).

语种：英文

外文摘要：Background: Molecular epidemiological studies have shown that gene polymorphisms of vitamin D receptor (VDR) are associated with prostate cancer risks. However, previous results from many molecular studies remain inconsistent. Methods: Blood samples were collected from 122 prostate cancer patients and 130 age-matched control subjects in the Han population of Southern China. The differences of VDR gene polymorphism between cancer cases and controls were determined by PCR-RFLP, examiming FokI (exon 2), BsmI, Tru9I, ApaI (intron 9), and TaqI (exon 9). Associations between the VDR gene polymorphism and prostate cancer risk were calculated in an unconditional logistic regression model. Linkage disequilibrium and haplotypes were analyzed with the SHEsis software. Results: Of five polymorphisms, BsmI was shown to associate with prostate cancer, while FokI, Tru9I, ApaI, and TaqI did not show any significant association. After adjustment for age, the BsmI 'B' allele was associated with an almost 1/3-fold risk (OR = 0.35, 95% CI: 0.15-0.80) of the occurrence of prostate cancer, a 1/5-fold risk (OR = 0.20, 95% CI: 0.06-0.68) of poorly differentiated prostate cancer, and a 1/10-fold risk (OR = 0.10, 95% CI: 0.01-0.78) of aggressive prostate cancer compared with the 'b' allele, especially among older men (>71 years). In addition, haplotype analysis revealed that the 'F-b-U-A-T' was more frequent found in cases than in controls (3.4% vs 0.0%, P = 0.0035), while the frequency of haplotype 'F-B-U-a-T' was 0.8% in cases, significantly lower than in controls (3.9%, P = 0.019). Conclusion: Our experiments provide evidences that genetic polymorphisms in the VDR gene may be potential risk factors for prostate cancer in the Han population of southern China and the susceptibility to prostate cancer is associated with ethnicity and geographic location.